TY - JOUR
T1 - Epstein-Barr virus and the origin of hodgkin lymphoma
AU - Vockerodt, Martina
AU - Cader, Fathima Zumla
AU - Shannon-Lowe, Claire
AU - Murray, Paul
N1 - Publisher Copyright:
© 2014 Landes Bioscience. All rights reserved.
PY - 2014/11/21
Y1 - 2014/11/21
N2 - Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
AB - Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.
KW - Chronic inflammation
KW - Epstein-Barr virus
KW - Hodgkin lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84909967045&partnerID=8YFLogxK
U2 - 10.5732/cjc.014.10193
DO - 10.5732/cjc.014.10193
M3 - Review article
C2 - 25418190
AN - SCOPUS:84909967045
SN - 1944-446X
VL - 33
SP - 591
EP - 597
JO - Chinese Journal of Cancer
JF - Chinese Journal of Cancer
IS - 12
ER -
