Epstein-Barr virus (EBV) and its associated human cancers - Genetics, epigenetics, pathobiology and novel therapeutics

Qian Tao, Lawrence S. Young, Ciaran B.J. Woodman, Paul G. Murray

Research output: Contribution to journalReview articlepeer-review

Abstract

Epstein-Barr virus (EBV) is a B-lymphotropic virus that is associated with a range of human malignancies. Although for many of these tumors the association has long been established, unraveling the precise role of EBV in disease pathogenesis has been more difficult. This review summarizes current knowledge concerning the association between EBV and human cancers, and illustrates how a deeper insight into viral latent gene expression, regulation and functions in different cell environments is already helping towards a better understanding of both the natural history of infection in normal individuals and how EBV contributes to malignant transformation. Finally, therapeutic strategies targeting EBV in tumors are discussed.

Original languageEnglish
Pages (from-to)2672-2713
Number of pages42
JournalFrontiers in bioscience : a journal and virtual library
Volume11
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2006
Externally publishedYes

Keywords

  • Apoptosis
  • Carcinoma
  • CpG
  • EBV
  • Epstein-Barr virus
  • Herpesvirus
  • Immortalization
  • Immunosuppression
  • Latent
  • Lymphoma
  • Lytic
  • Methylation
  • Nasopharyngeal
  • Persistence
  • Promoter
  • Review
  • Therapy
  • Transformation

Fingerprint

Dive into the research topics of 'Epstein-Barr virus (EBV) and its associated human cancers - Genetics, epigenetics, pathobiology and novel therapeutics'. Together they form a unique fingerprint.

Cite this