Epstein-Barr virus: More than 50 years old and still providing surprises

Lawrence S. Young; Lee Fah Yap; Paul G. Murray

doi:10.1038/nrc.2016.92

Epstein-Barr virus: More than 50 years old and still providing surprises

Lawrence S. Young
, Lee Fah Yap
, Paul G. Murray

Research output: Contribution to journal › Review article › peer-review

Abstract

It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer.

Original language	English
Pages (from-to)	789-802
Number of pages	14
Journal	Nature Reviews Cancer
Volume	16
Issue number	12
DOIs	https://doi.org/10.1038/nrc.2016.92
Publication status	Published - 1 Dec 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/nrc.2016.92

Cite this

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abstract = "It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer.",

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AB - It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer.

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Epstein-Barr virus: More than 50 years old and still providing surprises

Abstract

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