Epstein-Barr virus, the germinal centre and the development of Hodgkin's lymphoma

Ghada Mohamed, Katerina Vrzalikova, Fathima Zumla Cader, Martina Vockerodt, Eszter Nagy, Patrik Flodr, Lee Fah Yap, Arjan Diepstra, Philip M. Kluin, Stefano Rosati, Paul Murray

Research output: Contribution to journalReview articlepeer-review

Abstract

The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.

Original languageEnglish
Pages (from-to)1861-1869
Number of pages9
JournalJournal of General Virology
Volume95
Issue numberPART 9
DOIs
Publication statusPublished - Sep 2014
Externally publishedYes

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