TY - JOUR
T1 - Epstein-Barr virus, the germinal centre and the development of Hodgkin's lymphoma
AU - Mohamed, Ghada
AU - Vrzalikova, Katerina
AU - Cader, Fathima Zumla
AU - Vockerodt, Martina
AU - Nagy, Eszter
AU - Flodr, Patrik
AU - Yap, Lee Fah
AU - Diepstra, Arjan
AU - Kluin, Philip M.
AU - Rosati, Stefano
AU - Murray, Paul
N1 - © 2014 The Authors.
PY - 2014/9
Y1 - 2014/9
N2 - The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.
AB - The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.
UR - http://www.scopus.com/inward/record.url?scp=84906228866&partnerID=8YFLogxK
U2 - 10.1099/vir.0.066712-0
DO - 10.1099/vir.0.066712-0
M3 - Review article
C2 - 24893782
AN - SCOPUS:84906228866
SN - 0022-1317
VL - 95
SP - 1861
EP - 1869
JO - Journal of General Virology
JF - Journal of General Virology
IS - PART 9
ER -