TY - JOUR
T1 - Establishing outcome measures in early knee osteoarthritis
AU - Emery, Carolyn A.
AU - Whittaker, Jackie L.
AU - Mahmoudian, Armaghan
AU - Lohmander, L. Stefan
AU - Roos, Ewa M.
AU - Bennell, Kim L.
AU - Toomey, Clodagh M.
AU - Reimer, Raylene A.
AU - Thompson, Dylan
AU - Ronsky, Janet L.
AU - Kuntze, Gregor
AU - Lloyd, David G.
AU - Andriacchi, Thomas
AU - Englund, Martin
AU - Kraus, Virginia B.
AU - Losina, Elena
AU - Bierma-Zeinstra, Sita
AU - Runhaar, Jos
AU - Peat, George
AU - Luyten, Frank P.
AU - Snyder-Mackler, Lynn
AU - Risberg, May Arna
AU - Mobasheri, Ali
AU - Guermazi, Ali
AU - Hunter, David J.
AU - Arden, Nigel K.
N1 - Publisher Copyright:
© 2019, Springer Nature Limited.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.
AB - The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.
UR - http://www.scopus.com/inward/record.url?scp=85068051506&partnerID=8YFLogxK
U2 - 10.1038/s41584-019-0237-3
DO - 10.1038/s41584-019-0237-3
M3 - Article
C2 - 31201386
AN - SCOPUS:85068051506
SN - 1759-4790
VL - 15
SP - 438
EP - 448
JO - Nature Reviews Rheumatology
JF - Nature Reviews Rheumatology
IS - 7
ER -