Establishing outcome measures in early knee osteoarthritis

Carolyn A. Emery; Jackie L. Whittaker; Armaghan Mahmoudian; L. Stefan Lohmander; Ewa M. Roos; Kim L. Bennell; Clodagh M. Toomey; Raylene A. Reimer; Dylan Thompson; Janet L. Ronsky; Gregor Kuntze; David G. Lloyd; Thomas Andriacchi; Martin Englund; Virginia B. Kraus; Elena Losina; Sita Bierma-Zeinstra; Jos Runhaar; George Peat; Frank P. Luyten; Lynn Snyder-Mackler; May Arna Risberg; Ali Mobasheri; Ali Guermazi; David J. Hunter; Nigel K. Arden

doi:10.1038/s41584-019-0237-3

Establishing outcome measures in early knee osteoarthritis

Carolyn A. Emery
, Jackie L. Whittaker
, Armaghan Mahmoudian
, L. Stefan Lohmander
, Ewa M. Roos
, Kim L. Bennell
, Clodagh M. Toomey
, Raylene A. Reimer
, Dylan Thompson
, Janet L. Ronsky
, Gregor Kuntze
, David G. Lloyd
, Thomas Andriacchi
, Martin Englund
, Virginia B. Kraus
, Elena Losina
, Sita Bierma-Zeinstra
, Jos Runhaar
, George Peat
, Frank P. Luyten

Lynn Snyder-Mackler, May Arna Risberg, Ali Mobasheri, Ali Guermazi, David J. Hunter, Nigel K. Arden

University of Calgary
University of Alberta
KU Leuven
Lund University
University of Southern Denmark
University of Melbourne
University of Bath, Department for Health
Griffith University Queensland
Stanford University
Department of Veterans Affairs
Duke University
Boston University
Erasmus University Rotterdam
Keele University
University of Delaware
University of Oslo
State Research Institute Centre for Innovative Medicine
Nottingham University Hospitals NHS Trust
Kolling Instiitute of Medical Research
University of Oxford

Research output: Contribution to journal › Article › peer-review

Abstract

The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

Original language	English
Pages (from-to)	438-448
Number of pages	11
Journal	Nature Reviews Rheumatology
Volume	15
Issue number	7
DOIs	https://doi.org/10.1038/s41584-019-0237-3
Publication status	Published - 1 Jul 2019
Externally published	Yes

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Emery, C. A., Whittaker, J. L., Mahmoudian, A., Lohmander, L. S., Roos, E. M., Bennell, K. L., Toomey, C. M., Reimer, R. A., Thompson, D., Ronsky, J. L., Kuntze, G., Lloyd, D. G., Andriacchi, T., Englund, M., Kraus, V. B., Losina, E., Bierma-Zeinstra, S., Runhaar, J., Peat, G., ... Arden, N. K. (2019). Establishing outcome measures in early knee osteoarthritis. Nature Reviews Rheumatology, 15(7), 438-448. https://doi.org/10.1038/s41584-019-0237-3

@article{f5f43d49e7e94da4b542f7698dcc5369,

title = "Establishing outcome measures in early knee osteoarthritis",

abstract = "The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.",

author = "Emery, \{Carolyn A.\} and Whittaker, \{Jackie L.\} and Armaghan Mahmoudian and Lohmander, \{L. Stefan\} and Roos, \{Ewa M.\} and Bennell, \{Kim L.\} and Toomey, \{Clodagh M.\} and Reimer, \{Raylene A.\} and Dylan Thompson and Ronsky, \{Janet L.\} and Gregor Kuntze and Lloyd, \{David G.\} and Thomas Andriacchi and Martin Englund and Kraus, \{Virginia B.\} and Elena Losina and Sita Bierma-Zeinstra and Jos Runhaar and George Peat and Luyten, \{Frank P.\} and Lynn Snyder-Mackler and Risberg, \{May Arna\} and Ali Mobasheri and Ali Guermazi and Hunter, \{David J.\} and Arden, \{Nigel K.\}",

note = "Publisher Copyright: {\textcopyright} 2019, Springer Nature Limited.",

year = "2019",

month = jul,

day = "1",

doi = "10.1038/s41584-019-0237-3",

language = "English",

volume = "15",

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journal = "Nature Reviews Rheumatology",

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Emery, CA, Whittaker, JL, Mahmoudian, A, Lohmander, LS, Roos, EM, Bennell, KL, Toomey, CM, Reimer, RA, Thompson, D, Ronsky, JL, Kuntze, G, Lloyd, DG, Andriacchi, T, Englund, M, Kraus, VB, Losina, E, Bierma-Zeinstra, S, Runhaar, J, Peat, G, Luyten, FP, Snyder-Mackler, L, Risberg, MA, Mobasheri, A, Guermazi, A, Hunter, DJ & Arden, NK 2019, 'Establishing outcome measures in early knee osteoarthritis', Nature Reviews Rheumatology, vol. 15, no. 7, pp. 438-448. https://doi.org/10.1038/s41584-019-0237-3

TY - JOUR

T1 - Establishing outcome measures in early knee osteoarthritis

AU - Emery, Carolyn A.

AU - Whittaker, Jackie L.

AU - Mahmoudian, Armaghan

AU - Lohmander, L. Stefan

AU - Roos, Ewa M.

AU - Bennell, Kim L.

AU - Toomey, Clodagh M.

AU - Reimer, Raylene A.

AU - Thompson, Dylan

AU - Ronsky, Janet L.

AU - Kuntze, Gregor

AU - Lloyd, David G.

AU - Andriacchi, Thomas

AU - Englund, Martin

AU - Kraus, Virginia B.

AU - Losina, Elena

AU - Bierma-Zeinstra, Sita

AU - Runhaar, Jos

AU - Peat, George

AU - Luyten, Frank P.

AU - Snyder-Mackler, Lynn

AU - Risberg, May Arna

AU - Mobasheri, Ali

AU - Guermazi, Ali

AU - Hunter, David J.

AU - Arden, Nigel K.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

AB - The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

UR - https://www.scopus.com/pages/publications/85068051506

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DO - 10.1038/s41584-019-0237-3

M3 - Article

C2 - 31201386

AN - SCOPUS:85068051506

SN - 1759-4790

VL - 15

SP - 438

EP - 448

JO - Nature Reviews Rheumatology

JF - Nature Reviews Rheumatology

IS - 7

ER -

Establishing outcome measures in early knee osteoarthritis

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