TY - JOUR
T1 - Ethnic differences in prevalence of actionable HbA1c levels in UK Biobank
T2 - Implications for screening
AU - Anderson, Jana J.
AU - Welsh, Paul
AU - Ho, Frederick K.
AU - Ferguson, Lyn D.
AU - Welsh, Claire E.
AU - Pellicori, Pierpaolo
AU - Cleland, John G.F.
AU - Forbes, John
AU - Iliodromiti, Stamatina
AU - Boyle, James
AU - Lindsay, Robert
AU - Celis-Morales, Carlos
AU - Gray, Stuart Robert
AU - Katikireddi, Srinivasa Vittal
AU - Gill, Jason Martin Regnald
AU - Pell, Jill P.
AU - Sattar, Naveed
N1 - Publisher Copyright:
©
PY - 2021/8/5
Y1 - 2021/8/5
N2 - Introduction Early detection and treatment of diabetes as well as its prevention help lessen longer-term complications. We determined the prevalence of pre-diabetes and undiagnosed diabetes in the UK Biobank and standardized the results to the UK general population. Research design and methods This cross-sectional study analyzed baseline UK Biobank data on plasma glycated hemoglobin (HbA1c) to compare the prevalence of pre-diabetes and undiagnosed diabetes mellitus in white, South Asian, black, and Chinese participants. The overall and ethnic-specific results were standardized to the UK general population aged 40-70 years of age. Results Within the UK Biobank, the overall crude prevalence was 3.6% for pre-diabetes, 0.8% for undiagnosed diabetes, and 4.4% for either. Following standardization to the UK general population, the results were similar at 3.8%, 0.8%, and 4.7%, respectively. Crude prevalence was much higher in South Asian (11.0% pre-diabetes; 3.6% undiagnosed diabetes; 14.6% either) or black (13.8% pre-diabetes; 3.0% undiagnosed diabetes; 16.8% either) participants. Only six middle-aged or old-aged South Asian individuals or seven black would need to be tested to identify an HbA1c result that merits action. Conclusions Single-stage population screening for pre-diabetes or undiagnosed diabetes in middle-old or old-aged South Asian and black individuals using HbA1c could be efficient and should be considered.
AB - Introduction Early detection and treatment of diabetes as well as its prevention help lessen longer-term complications. We determined the prevalence of pre-diabetes and undiagnosed diabetes in the UK Biobank and standardized the results to the UK general population. Research design and methods This cross-sectional study analyzed baseline UK Biobank data on plasma glycated hemoglobin (HbA1c) to compare the prevalence of pre-diabetes and undiagnosed diabetes mellitus in white, South Asian, black, and Chinese participants. The overall and ethnic-specific results were standardized to the UK general population aged 40-70 years of age. Results Within the UK Biobank, the overall crude prevalence was 3.6% for pre-diabetes, 0.8% for undiagnosed diabetes, and 4.4% for either. Following standardization to the UK general population, the results were similar at 3.8%, 0.8%, and 4.7%, respectively. Crude prevalence was much higher in South Asian (11.0% pre-diabetes; 3.6% undiagnosed diabetes; 14.6% either) or black (13.8% pre-diabetes; 3.0% undiagnosed diabetes; 16.8% either) participants. Only six middle-aged or old-aged South Asian individuals or seven black would need to be tested to identify an HbA1c result that merits action. Conclusions Single-stage population screening for pre-diabetes or undiagnosed diabetes in middle-old or old-aged South Asian and black individuals using HbA1c could be efficient and should be considered.
KW - diabetes mellitus
KW - early diagnosis
KW - ethnic groups
KW - glycated hemoglobin A
KW - type 2
UR - http://www.scopus.com/inward/record.url?scp=85112343536&partnerID=8YFLogxK
U2 - 10.1136/bmjdrc-2021-002176
DO - 10.1136/bmjdrc-2021-002176
M3 - Article
C2 - 34353880
AN - SCOPUS:85112343536
SN - 2052-4897
VL - 9
JO - BMJ Open Diabetes Research and Care
JF - BMJ Open Diabetes Research and Care
IS - 1
M1 - 002176
ER -