Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase

Gerhard Buse; Tewfik Soulimane; Manfred Dewor; Helmut E. Meyer; Martin Blüggel

doi:10.1110/ps.8.5.985

Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase

Gerhard Buse, Tewfik Soulimane, Manfred Dewor, Helmut E. Meyer, Martin Blüggel

Research output: Contribution to journal › Article › peer-review

Abstract

Following hints from X-ray data (Ostermeier C et al., 1997, Proc Natl Acad Sci USA 94:10547-10553; Yoshikawa S et al., 1998, Science 280:1723- 1729), chemical evidence is presented from four distantly related cytochrome- c oxidases for the existence of a copper(B)-coordinated His240-Tyr244) cross- link at the O₂-activating Heme Fea₃-Cu(B) center in the catalytic subunit I of the enzyme. The early evolutionary invention of this unusual structure may have prevented demaging ·OH-radical release at e^--transfer to dioxygen and thus have enabled O₂ respiration.

Original language	English
Pages (from-to)	985-990
Number of pages	6
Journal	Protein Science
Volume	8
Issue number	5
DOIs	https://doi.org/10.1110/ps.8.5.985
Publication status	Published - 1999
Externally published	Yes

Keywords

Cell respiration
Cytochrome-c oxidase
Histidine-tyrosine cross-link
O activation
Oxygen radicals

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10.1110/ps.8.5.985

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title = "Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase",

abstract = "Following hints from X-ray data (Ostermeier C et al., 1997, Proc Natl Acad Sci USA 94:10547-10553; Yoshikawa S et al., 1998, Science 280:1723- 1729), chemical evidence is presented from four distantly related cytochrome- c oxidases for the existence of a copper(B)-coordinated His240-Tyr244) cross- link at the O2-activating Heme Fea3-Cu(B) center in the catalytic subunit I of the enzyme. The early evolutionary invention of this unusual structure may have prevented demaging ·OH-radical release at e--transfer to dioxygen and thus have enabled O2 respiration.",

keywords = "Cell respiration, Cytochrome-c oxidase, Histidine-tyrosine cross-link, O activation, Oxygen radicals",

author = "Gerhard Buse and Tewfik Soulimane and Manfred Dewor and Meyer, \{Helmut E.\} and Martin Bl{\"u}ggel",

year = "1999",

doi = "10.1110/ps.8.5.985",

language = "English",

volume = "8",

pages = "985--990",

journal = "Protein Science",

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TY - JOUR

T1 - Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase

AU - Buse, Gerhard

AU - Soulimane, Tewfik

AU - Dewor, Manfred

AU - Meyer, Helmut E.

AU - Blüggel, Martin

PY - 1999

Y1 - 1999

N2 - Following hints from X-ray data (Ostermeier C et al., 1997, Proc Natl Acad Sci USA 94:10547-10553; Yoshikawa S et al., 1998, Science 280:1723- 1729), chemical evidence is presented from four distantly related cytochrome- c oxidases for the existence of a copper(B)-coordinated His240-Tyr244) cross- link at the O2-activating Heme Fea3-Cu(B) center in the catalytic subunit I of the enzyme. The early evolutionary invention of this unusual structure may have prevented demaging ·OH-radical release at e--transfer to dioxygen and thus have enabled O2 respiration.

AB - Following hints from X-ray data (Ostermeier C et al., 1997, Proc Natl Acad Sci USA 94:10547-10553; Yoshikawa S et al., 1998, Science 280:1723- 1729), chemical evidence is presented from four distantly related cytochrome- c oxidases for the existence of a copper(B)-coordinated His240-Tyr244) cross- link at the O2-activating Heme Fea3-Cu(B) center in the catalytic subunit I of the enzyme. The early evolutionary invention of this unusual structure may have prevented demaging ·OH-radical release at e--transfer to dioxygen and thus have enabled O2 respiration.

KW - Cell respiration

KW - Cytochrome-c oxidase

KW - Histidine-tyrosine cross-link

KW - O activation

KW - Oxygen radicals

UR - https://www.scopus.com/pages/publications/0032924497

U2 - 10.1110/ps.8.5.985

DO - 10.1110/ps.8.5.985

M3 - Article

C2 - 10338009

AN - SCOPUS:0032924497

SN - 0961-8368

VL - 8

SP - 985

EP - 990

JO - Protein Science

JF - Protein Science

IS - 5

ER -

Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase

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Keywords

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