TY - JOUR
T1 - Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics
AU - Kar, Rishav
AU - Dhar, Rajib
AU - Mukherjee, Sayantanee
AU - Nag, Sagnik
AU - Gorai, Sukhamoy
AU - Mukerjee, Nobendu
AU - Mukherjee, Dattatreya
AU - Vatsa, Rishabh
AU - Chandrakanth Jadhav, Mamtha
AU - Ghosh, Arabinda
AU - Devi, Arikketh
AU - Krishnan, Anand
AU - Thorat, Nanasaheb D.
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2023/2/13
Y1 - 2023/2/13
N2 - Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.
AB - Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.
KW - Eexosomes
KW - cancer
KW - cancer biomarker
KW - drug delivery
KW - drug loading methods
UR - http://www.scopus.com/inward/record.url?scp=85146172976&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.2c01329
DO - 10.1021/acsbiomaterials.2c01329
M3 - Review article
C2 - 36621949
AN - SCOPUS:85146172976
SN - 2373-9878
VL - 9
SP - 577
EP - 594
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 2
ER -