Exosome-mediated PROTAC delivery for treatment of RNA viral infections and zoonosis

Nobendu Mukerjee, Swastika Maitra, Arabinda Ghosh, Athanasios Alexiou, Nanasaheb D. Thorat

Research output: Contribution to journalShort surveypeer-review

Abstract

The increase in diseases caused by RNA viruses, such as influenza, severe acute respiratory syndrome-coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS), and Ebola, presents a growing global health challenge as well as the threat of zoonosis. Traditional antiviral treatments are often undermined by fast-mutating viruses, drug resistance, and newly emerging pathogens. Here, we explore proteolysis-targeting chimeras (PROTACs), a novel protein degradation machinery that has the potential to reshape the way in which RNA viral infections can be managed. PROTACs excel at specifically degrading pathogenic proteins, offering a targeted and efficient antiviral strategy. We also investigate the potential of exosome-based diagnostic technologies, which harness cell-derived nanovesicles for non-invasive sampling and early viral infection detection. Addressing the challenge of PROTAC delivery, we introduce a groundbreaking strategy utilizing exosomes to deliver PROTACs with improved precision and as a targeted delivery vehicle. Integrating these innovative strategies provides a novel approach to combat RNA zoonotic viral diseases, paving the way for a new era in antiviral therapy.

Original languageEnglish
Article number104044
JournalDrug Discovery Today
Volume29
Issue number7
DOIs
Publication statusPublished - Jul 2024

Keywords

  • antiviral therapy
  • chipset
  • exosome-mediated delivery
  • PROTACs
  • RNA viral infections
  • targeted protein degradation
  • zoonosis

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