TY - CHAP
T1 - Extracellular Vesicles and Cancer Therapy
AU - Dey, Dwaipayan
AU - Kar, Rishav
AU - Mukherjee, Dattatreya
AU - Mirgh, Divya
AU - Deb Adhikari, Manab
AU - Krishnan, Anand
AU - Thorat, Nanasaheb
AU - Gorai, Sukhamoy
N1 - Publisher Copyright:
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Cancer is a complex health crisis worldwide. The study of extracellular vesicles (EVs) research brings a cutting-edge episode in cancer research. EVs explain cancer biology in an innovative way by participating in several cellular events. It also displays the cellular status (health or pathological condition). In cancer, tumor-derived EVs (especially called tumor-derived exosomes—TEXs) are associated with cancer development and progression related to multiple functions. Exosomes (a subpopulation of EVs) are keys to regulating cancer-related multiple events such as cancer cell proliferation, angiogenesis, immune cell reprogramming, metastasis, drug and therapeutic resistance. It is a molecular signature messenger of cancer biomarkers. EVs-based liquid biopsy (patient's blood, plasma serum, saliva, urine, etc.) transforms cancer screening into a more accurate manner (early detection and therapeutic efficiency check). Based on the source (stem cells, plants, TEXs) of EVs, promising anticancer activity is being shown. The most exciting fact about EVs-based cancer therapy is its greater efficiency due to its biocompatibility, low toxicity, lower immune reactivity, and ability to cross biological barriers. EVs are considered promising to deliver drug, and therapeutic molecules to the specific site of the disease. Currently, EVs platform-based cancer therapeutic development is considered one of the most promising ways to combat the global cancer crisis.
AB - Cancer is a complex health crisis worldwide. The study of extracellular vesicles (EVs) research brings a cutting-edge episode in cancer research. EVs explain cancer biology in an innovative way by participating in several cellular events. It also displays the cellular status (health or pathological condition). In cancer, tumor-derived EVs (especially called tumor-derived exosomes—TEXs) are associated with cancer development and progression related to multiple functions. Exosomes (a subpopulation of EVs) are keys to regulating cancer-related multiple events such as cancer cell proliferation, angiogenesis, immune cell reprogramming, metastasis, drug and therapeutic resistance. It is a molecular signature messenger of cancer biomarkers. EVs-based liquid biopsy (patient's blood, plasma serum, saliva, urine, etc.) transforms cancer screening into a more accurate manner (early detection and therapeutic efficiency check). Based on the source (stem cells, plants, TEXs) of EVs, promising anticancer activity is being shown. The most exciting fact about EVs-based cancer therapy is its greater efficiency due to its biocompatibility, low toxicity, lower immune reactivity, and ability to cross biological barriers. EVs are considered promising to deliver drug, and therapeutic molecules to the specific site of the disease. Currently, EVs platform-based cancer therapeutic development is considered one of the most promising ways to combat the global cancer crisis.
KW - Cancer
KW - Extracellular vesicles
KW - Metastasis
KW - Therapeutics
UR - http://www.scopus.com/inward/record.url?scp=86000699537&partnerID=8YFLogxK
U2 - 10.1007/978-981-97-2494-9_11
DO - 10.1007/978-981-97-2494-9_11
M3 - Chapter
AN - SCOPUS:86000699537
SN - 9789819724932
SP - 215
EP - 228
BT - Extracellular Vesicles in Human Health and Diseases
PB - Springer Nature
ER -
