Extractant selection strategy for solvent-impregnated resins in fermentations

Corjan Van den Berg; Mark Roelands; Paul Bussmann; Earl Goetheer; Dirk Verdoes; Luuk Van der Wielen

doi:10.1021/ie800973y

Extractant selection strategy for solvent-impregnated resins in fermentations

Corjan Van den Berg, Mark Roelands, Paul Bussmann, Earl Goetheer, Dirk Verdoes, Luuk Van der Wielen

Research output: Contribution to journal › Article › peer-review

Abstract

The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P _o/w values), product selectivity, and extractant regeneration.

Original language	English
Pages (from-to)	10071-10075
Number of pages	5
Journal	Industrial and Engineering Chemistry Research
Volume	47
Issue number	24
DOIs	https://doi.org/10.1021/ie800973y
Publication status	Published - 17 Dec 2008
Externally published	Yes

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10.1021/ie800973y

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title = "Extractant selection strategy for solvent-impregnated resins in fermentations",

abstract = "The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration.",

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AU - Van den Berg, Corjan

AU - Roelands, Mark

AU - Bussmann, Paul

AU - Goetheer, Earl

AU - Verdoes, Dirk

AU - Van der Wielen, Luuk

PY - 2008/12/17

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N2 - The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration.

AB - The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration.

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JO - Industrial and Engineering Chemistry Research

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Extractant selection strategy for solvent-impregnated resins in fermentations

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