TY - JOUR
T1 - Fatigue-Related Changes of Daily Function
T2 - Most Promising Measures for the Digital Age
AU - Maetzler, Walter
AU - Correia Guedes, Leonor
AU - Emmert, Kirsten Nele
AU - Kudelka, Jennifer
AU - Hildesheim, Hanna Luise
AU - Paulides, Emma
AU - Connolly, Hayley
AU - Davies, Kristen
AU - Dilda, Valentina
AU - Ahmaniemi, Teemu
AU - Avedano, Luisa
AU - Bouça-Machado, Raquel
AU - Chambers, Michael
AU - Chatterjee, Meenakshi
AU - Gallagher, Peter
AU - Graeber, Johanna
AU - Maetzler, Corina
AU - Kaduszkiewicz, Hanna
AU - Kennedy, Norelee
AU - MacRae, Victoria
AU - Carrasco Marín, Laura
AU - Moses, Anusha
AU - Padovani, Alessandro
AU - Pilotto, Andrea
AU - Ratcliffe, Natasha
AU - Reilmann, Ralf
AU - Rosario, Madalena
AU - Schreiber, Stefan
AU - De Sousa, Dina
AU - Van Gassen, Geert
AU - Warring, Lori Ann
AU - Seppi, Klaus
AU - Van Der Woude, C. Janneke
AU - Ferreira, Joaquim J.
AU - Ng, Wan Fai
N1 - Publisher Copyright:
© 2024 S. Karger AG, Basel.
PY - 2024/3/20
Y1 - 2024/3/20
N2 - Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the recent advances of digital wearable technologies, novel approaches to evaluate daily function quantitatively and objectively in real-life conditions are increasingly possible. This also creates new possibilities to measure fatigue-related changes of daily function using such technologies. Summary: This review examines which digitally assessable parameters in immune-mediated inflammatory and neurodegenerative diseases may have the greatest potential to reflect fatigue-related changes of daily function. Key Messages: Results of a standardized analysis of the literature reporting about perception-, capacity-, and performance-evaluating assessment tools indicate that changes of the following parameters: physical activity, independence of daily living, social participation, working life, mental status, cognitive and aerobic capacity, and supervised and unsupervised mobility performance have the highest potential to reflect fatigue-related changes of daily function. These parameters thus hold the greatest potential for quantitatively measuring fatigue in representative diseases in real-life conditions, e.g., with digital wearable technologies. Furthermore, to the best of our knowledge, this is a new approach to analysing evidence for the design of performance-based digital assessment protocols in human research, which may stimulate further systematic research in this area.
AB - Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the recent advances of digital wearable technologies, novel approaches to evaluate daily function quantitatively and objectively in real-life conditions are increasingly possible. This also creates new possibilities to measure fatigue-related changes of daily function using such technologies. Summary: This review examines which digitally assessable parameters in immune-mediated inflammatory and neurodegenerative diseases may have the greatest potential to reflect fatigue-related changes of daily function. Key Messages: Results of a standardized analysis of the literature reporting about perception-, capacity-, and performance-evaluating assessment tools indicate that changes of the following parameters: physical activity, independence of daily living, social participation, working life, mental status, cognitive and aerobic capacity, and supervised and unsupervised mobility performance have the highest potential to reflect fatigue-related changes of daily function. These parameters thus hold the greatest potential for quantitatively measuring fatigue in representative diseases in real-life conditions, e.g., with digital wearable technologies. Furthermore, to the best of our knowledge, this is a new approach to analysing evidence for the design of performance-based digital assessment protocols in human research, which may stimulate further systematic research in this area.
KW - Activities of daily life
KW - International Classification of Functioning, disability and health Performance
KW - Wearables
UR - http://www.scopus.com/inward/record.url?scp=85190369839&partnerID=8YFLogxK
U2 - 10.1159/000536568
DO - 10.1159/000536568
M3 - Review article
AN - SCOPUS:85190369839
SN - 2504-110X
VL - 8
SP - 30
EP - 39
JO - Digital Biomarkers
JF - Digital Biomarkers
IS - 1
ER -