Feasibility of the thermodynamically controlled synthesis of amoxicillin

M. B. Diender, A. J.J. Straathof, L. A.M. Van Der Wielen, C. Ras, J. J. Heijnen

Research output: Contribution to journalArticlepeer-review

Abstract

The enzymatic, thermodynamically controlled synthesis of amoxiciliin in aqueous solution was measured in order to study the feasibility of a 'solid- to-solid' conversion. In aqueous solution, however, the synthetic yield of amoxicillin remains lower than the amoxicillin solubility. Therefore, a 'solid-to-solid' synthesis of amoxicillin in aqueous solution is not feasible. Synthetic yields in enzymatic condensation reactions can often be improved by adding organic solvents in monophasic systems. Addition of cosolvents is calculated to improve the apparent equilibrium constant of amoxicillin synthesis considerably, but probably not the synthetic yield, due to solubility restrictions of the reactants.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalJournal of Molecular Catalysis B: Enzymatic
Volume5
Issue number1-4
DOIs
Publication statusPublished - 15 Sep 1998
Externally publishedYes

Keywords

  • Amoxicillin
  • Solid-to-solid conversion
  • Thermodynamically controlled synthesis

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