TY - JOUR
T1 - Feasibility of the thermodynamically controlled synthesis of amoxicillin
AU - Diender, M. B.
AU - Straathof, A. J.J.
AU - Van Der Wielen, L. A.M.
AU - Ras, C.
AU - Heijnen, J. J.
PY - 1998/9/15
Y1 - 1998/9/15
N2 - The enzymatic, thermodynamically controlled synthesis of amoxiciliin in aqueous solution was measured in order to study the feasibility of a 'solid- to-solid' conversion. In aqueous solution, however, the synthetic yield of amoxicillin remains lower than the amoxicillin solubility. Therefore, a 'solid-to-solid' synthesis of amoxicillin in aqueous solution is not feasible. Synthetic yields in enzymatic condensation reactions can often be improved by adding organic solvents in monophasic systems. Addition of cosolvents is calculated to improve the apparent equilibrium constant of amoxicillin synthesis considerably, but probably not the synthetic yield, due to solubility restrictions of the reactants.
AB - The enzymatic, thermodynamically controlled synthesis of amoxiciliin in aqueous solution was measured in order to study the feasibility of a 'solid- to-solid' conversion. In aqueous solution, however, the synthetic yield of amoxicillin remains lower than the amoxicillin solubility. Therefore, a 'solid-to-solid' synthesis of amoxicillin in aqueous solution is not feasible. Synthetic yields in enzymatic condensation reactions can often be improved by adding organic solvents in monophasic systems. Addition of cosolvents is calculated to improve the apparent equilibrium constant of amoxicillin synthesis considerably, but probably not the synthetic yield, due to solubility restrictions of the reactants.
KW - Amoxicillin
KW - Solid-to-solid conversion
KW - Thermodynamically controlled synthesis
UR - http://www.scopus.com/inward/record.url?scp=0032530915&partnerID=8YFLogxK
U2 - 10.1016/S1381-1177(98)00044-7
DO - 10.1016/S1381-1177(98)00044-7
M3 - Article
AN - SCOPUS:0032530915
SN - 1381-1177
VL - 5
SP - 249
EP - 253
JO - Journal of Molecular Catalysis B: Enzymatic
JF - Journal of Molecular Catalysis B: Enzymatic
IS - 1-4
ER -