TY - JOUR
T1 - Food bioactive compounds and emerging techniques for their extraction
T2 - Polyphenols as a case study
AU - Câmara, José S.
AU - Albuquerque, Bianca R.
AU - Aguiar, Joselin
AU - Corrêa, Rúbia C.G.
AU - Gonçalves, João L.
AU - Granato, Daniel
AU - Pereira, Jorge A.M.
AU - Barros, Lillian
AU - Ferreira, Isabel C.F.R.
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1
Y1 - 2021/1
N2 - Experimental studies have provided convincing evidence that food bioactive compounds (FBCs) have a positive biological impact on human health, exerting protective effects against noncommunicable diseases (NCD) including cancer and cardiovascular (CVDs), metabolic, and neurodegenerative disorders (NDDs). These benefits have been associated with the presence of secondary metabolites, namely polyphenols, glucosinolates, carotenoids, terpenoids, alkaloids, saponins, vitamins, and fibres, among others, derived from their antioxidant, antiatherogenic, anti-inflammatory, antimicrobial, antithrombotic, cardioprotective, and vasodilator properties. Polyphenols as one of the most abundant classes of bioactive compounds present in plant-based foods emerge as a promising approach for the development of efficacious preventive agents against NCDs with reduced side effects. The aim of this review is to present comprehensive and deep insights into the potential of polyphenols, from their chemical structure classification and biosynthesis to preventive effects on NCDs, namely cancer, CVDs, and NDDS. The challenge of polyphenols bioavailability and bioaccessibility will be explored in addition to useful industrial and environmental applications. Advanced and emerging extraction techniques will be highlighted and the high-resolution analytical techniques used for FBCs characterization, identification, and quantification will be considered.
AB - Experimental studies have provided convincing evidence that food bioactive compounds (FBCs) have a positive biological impact on human health, exerting protective effects against noncommunicable diseases (NCD) including cancer and cardiovascular (CVDs), metabolic, and neurodegenerative disorders (NDDs). These benefits have been associated with the presence of secondary metabolites, namely polyphenols, glucosinolates, carotenoids, terpenoids, alkaloids, saponins, vitamins, and fibres, among others, derived from their antioxidant, antiatherogenic, anti-inflammatory, antimicrobial, antithrombotic, cardioprotective, and vasodilator properties. Polyphenols as one of the most abundant classes of bioactive compounds present in plant-based foods emerge as a promising approach for the development of efficacious preventive agents against NCDs with reduced side effects. The aim of this review is to present comprehensive and deep insights into the potential of polyphenols, from their chemical structure classification and biosynthesis to preventive effects on NCDs, namely cancer, CVDs, and NDDS. The challenge of polyphenols bioavailability and bioaccessibility will be explored in addition to useful industrial and environmental applications. Advanced and emerging extraction techniques will be highlighted and the high-resolution analytical techniques used for FBCs characterization, identification, and quantification will be considered.
KW - Bioavailability and bioaccessibility
KW - Cancer
KW - Cardiovascular diseases (CVDs)
KW - Disease protection
KW - Food bioactive compounds (FBCs)
KW - Neurodegenerative diseases (NDs)
KW - Polyphenols
UR - http://www.scopus.com/inward/record.url?scp=85103000119&partnerID=8YFLogxK
U2 - 10.3390/foods10010037
DO - 10.3390/foods10010037
M3 - Review article
AN - SCOPUS:85103000119
SN - 2304-8158
VL - 10
JO - Foods
JF - Foods
IS - 1
M1 - 37
ER -
