Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

Jianming Ying; Zifen Gao; Hongyu Li; Gopesh Srivastava; Paul G. Murray; Hwee Koon Goh; Chai Yen Lim; Yajun Wang; Teresa Marafioti; David Y. Mason; Richard F. Ambinder; Anthony T.C. Chan; Qian Tao

doi:10.1111/j.1365-2141.2007.06512.x

Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

Jianming Ying
, Zifen Gao
, Hongyu Li
, Gopesh Srivastava
, Paul G. Murray
, Hwee Koon Goh
, Chai Yen Lim
, Yajun Wang
, Teresa Marafioti
, David Y. Mason
, Richard F. Ambinder
, Anthony T.C. Chan
, Qian Tao

Research output: Contribution to journal › Article › peer-review

Abstract

Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

Original language	English
Pages (from-to)	829-832
Number of pages	4
Journal	British Journal of Haematology
Volume	136
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06512.x
Publication status	Published - Mar 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomarker
Lymphoma
Methylation
PCDH10
Tumour suppressor gene

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10.1111/j.1365-2141.2007.06512.x

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Ying, J., Gao, Z., Li, H., Srivastava, G., Murray, P. G., Goh, H. K., Lim, C. Y., Wang, Y., Marafioti, T., Mason, D. Y., Ambinder, R. F., Chan, A. T. C., & Tao, Q. (2007). Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies. British Journal of Haematology, 136(6), 829-832. https://doi.org/10.1111/j.1365-2141.2007.06512.x

@article{03821881ce54442c96f06fe624cef1b6,

title = "Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies",

abstract = "Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100\% Burkitt, 100\% diffuse large B cell, 86\% Hodgkin, 100\% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14\% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.",

keywords = "Biomarker, Lymphoma, Methylation, PCDH10, Tumour suppressor gene",

author = "Jianming Ying and Zifen Gao and Hongyu Li and Gopesh Srivastava and Murray, \{Paul G.\} and Goh, \{Hwee Koon\} and Lim, \{Chai Yen\} and Yajun Wang and Teresa Marafioti and Mason, \{David Y.\} and Ambinder, \{Richard F.\} and Chan, \{Anthony T.C.\} and Qian Tao",

year = "2007",

month = mar,

doi = "10.1111/j.1365-2141.2007.06512.x",

language = "English",

volume = "136",

pages = "829--832",

journal = "British Journal of Haematology",

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T1 - Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

AU - Ying, Jianming

AU - Gao, Zifen

AU - Li, Hongyu

AU - Srivastava, Gopesh

AU - Murray, Paul G.

AU - Goh, Hwee Koon

AU - Lim, Chai Yen

AU - Wang, Yajun

AU - Marafioti, Teresa

AU - Mason, David Y.

AU - Ambinder, Richard F.

AU - Chan, Anthony T.C.

AU - Tao, Qian

PY - 2007/3

Y1 - 2007/3

N2 - Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

AB - Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.

KW - Biomarker

KW - Lymphoma

KW - Methylation

KW - PCDH10

KW - Tumour suppressor gene

UR - https://www.scopus.com/pages/publications/33847379460

U2 - 10.1111/j.1365-2141.2007.06512.x

DO - 10.1111/j.1365-2141.2007.06512.x

M3 - Article

C2 - 17341268

AN - SCOPUS:33847379460

SN - 0007-1048

VL - 136

SP - 829

EP - 832

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

Abstract

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Keywords

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