TY - JOUR
T1 - From waste to the gut
T2 - Can blackcurrant press cake be a new functional ingredient? Insights on in vivo microbiota modulation, oxidative stress, and inflammation
AU - dos Santos Lima, Amanda
AU - Novaes, Rômulo Dias
AU - Pinheiro, Lucas Cezar
AU - de Almeida, Leonardo Augusto
AU - Martino, Hercia Stampini Duarte
AU - Giusti-Paiva, Alexandre
AU - Pap, Nora
AU - Granato, Daniel
AU - Azevedo, Luciana
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/8
Y1 - 2023/8
N2 - Blackcurrant press cake (BPC) is a source of anthocyanins, and this study evaluated the bioactivity and gut microbiota modulation of blackcurrant diets with or without 1,2 dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. In colon cancer-induced rats (CRC), BPC at the highest dosages increased pro-inflammatory parameters and the expression of anti-apoptotic cytokines, accentuating colon cancer initiation by aberrant crypts and morphological changes. Fecal microbiome analysis showed that BPC altered the composition and function of the gut microbiome. This evidence suggests that high doses of BPC act as a pro-oxidant, accentuating the inflammatory environment and CRC progression.
AB - Blackcurrant press cake (BPC) is a source of anthocyanins, and this study evaluated the bioactivity and gut microbiota modulation of blackcurrant diets with or without 1,2 dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. In colon cancer-induced rats (CRC), BPC at the highest dosages increased pro-inflammatory parameters and the expression of anti-apoptotic cytokines, accentuating colon cancer initiation by aberrant crypts and morphological changes. Fecal microbiome analysis showed that BPC altered the composition and function of the gut microbiome. This evidence suggests that high doses of BPC act as a pro-oxidant, accentuating the inflammatory environment and CRC progression.
KW - Aberrant crypt foci (ACF)
KW - Anthocyanins
KW - Blackcurrant
KW - By-product
KW - Colorectal carcinogenesis
KW - Gut microbiota modulation
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85159357437&partnerID=8YFLogxK
U2 - 10.1016/j.foodres.2023.112917
DO - 10.1016/j.foodres.2023.112917
M3 - Article
C2 - 37316039
AN - SCOPUS:85159357437
SN - 0963-9969
VL - 170
SP - 112917
JO - Food Research International
JF - Food Research International
M1 - 112917
ER -