TY - JOUR
T1 - Ginkgo biloba as an alternative medicine in the treatment of anxiety in dementia and other psychiatric disorders
AU - Singh, Sandeep Kumar
AU - Barreto, George E.
AU - Aliev, Gjumrakch
AU - Echeverria, Valentina
N1 - Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: Mental disorders are the most common health problems in the worldwide population. Current medicines against these conditions have undesired side effects or limited effectiveness. These disadvantageous pharmacological and therapeutic characteristics provoke a low adherence to treatment in an important percentage of patients with mental disorders. Since ancient times, ethnically different groups have been using plants extracts as medicines for the treatment of mental conditions including dementia, depression and anxiety disorders. Among them are extracts of Ginkgo biloba, a tree in the division Gingophyta, that has been used by millions of people worldwide. Objective: This review aims to discuss current scientific evidence of efficacy, neuroprotective and antioxidant effects as mechanism of action, side effects and potential interaction with other commonly prescribed anxiolytic drugs. Methods: A PubMed search of preclinical studies as well as individual clinical trials and meta-analysis were scrutinized. Results: Various preclinical and clinical studies have shown a positive effect of Ginkgo biloba to improve cognitive abilities in impaired individuals and reducing anxiety under pathological conditions. Conclusion: A more advanced clinical research is needed to confirm the efficacy of Gingko biloba for the treatment of anxiety in different health conditions.
AB - Background: Mental disorders are the most common health problems in the worldwide population. Current medicines against these conditions have undesired side effects or limited effectiveness. These disadvantageous pharmacological and therapeutic characteristics provoke a low adherence to treatment in an important percentage of patients with mental disorders. Since ancient times, ethnically different groups have been using plants extracts as medicines for the treatment of mental conditions including dementia, depression and anxiety disorders. Among them are extracts of Ginkgo biloba, a tree in the division Gingophyta, that has been used by millions of people worldwide. Objective: This review aims to discuss current scientific evidence of efficacy, neuroprotective and antioxidant effects as mechanism of action, side effects and potential interaction with other commonly prescribed anxiolytic drugs. Methods: A PubMed search of preclinical studies as well as individual clinical trials and meta-analysis were scrutinized. Results: Various preclinical and clinical studies have shown a positive effect of Ginkgo biloba to improve cognitive abilities in impaired individuals and reducing anxiety under pathological conditions. Conclusion: A more advanced clinical research is needed to confirm the efficacy of Gingko biloba for the treatment of anxiety in different health conditions.
KW - Alzheimer
KW - Anxiety
KW - Medicinal plants
KW - Neurodegeneration
KW - Neuroinflammation
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85017419641&partnerID=8YFLogxK
U2 - 10.2174/1389200217666161201112206
DO - 10.2174/1389200217666161201112206
M3 - Review article
C2 - 27908257
AN - SCOPUS:85017419641
SN - 1389-2002
VL - 18
SP - 112
EP - 119
JO - Current Drug Metabolism
JF - Current Drug Metabolism
IS - 2
ER -