Glial modulation by N-acylethanolamides in brain injury and neurodegeneration

María I. Herrera; Rodolfo Kölliker-Frers; George Barreto; Eduardo Blanco; Francisco Capani

doi:10.3389/fnagi.2016.00081

Glial modulation by N-acylethanolamides in brain injury and neurodegeneration

María I. Herrera
, Rodolfo Kölliker-Frers
, George Barreto
, Eduardo Blanco
, Francisco Capani

Research output: Contribution to journal › Short survey › peer-review

Abstract

Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.

Original language	English
Article number	81
Journal	Frontiers in Aging Neuroscience
Volume	8
Issue number	APR
DOIs	https://doi.org/10.3389/fnagi.2016.00081
Publication status	Published - 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gliosis
N-acylethanolamides
Neuroinflammation
Neuroprotection
PPARα

Access to Document

10.3389/fnagi.2016.00081

Cite this

@article{e764ffce7f7d4d91979d5f8ec679472c,

title = "Glial modulation by N-acylethanolamides in brain injury and neurodegeneration",

abstract = "Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.",

keywords = "Gliosis, N-acylethanolamides, Neuroinflammation, Neuroprotection, PPARα",

author = "Herrera, \{Mar{\'i}a I.\} and Rodolfo K{\"o}lliker-Frers and George Barreto and Eduardo Blanco and Francisco Capani",

note = "Publisher Copyright: {\textcopyright} 2016 Herrera, K{\"o}lliker-Frers, Barreto, Blanco and Capani.",

year = "2016",

doi = "10.3389/fnagi.2016.00081",

language = "English",

volume = "8",

journal = "Frontiers in Aging Neuroscience",

issn = "1663-4365",

number = "APR",

}

TY - JOUR

T1 - Glial modulation by N-acylethanolamides in brain injury and neurodegeneration

AU - Herrera, María I.

AU - Kölliker-Frers, Rodolfo

AU - Barreto, George

AU - Blanco, Eduardo

AU - Capani, Francisco

PY - 2016

Y1 - 2016

N2 - Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.

AB - Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.

KW - Gliosis

KW - N-acylethanolamides

KW - Neuroinflammation

KW - Neuroprotection

KW - PPARα

UR - https://www.scopus.com/pages/publications/84974588687

U2 - 10.3389/fnagi.2016.00081

DO - 10.3389/fnagi.2016.00081

M3 - Short survey

AN - SCOPUS:84974588687

SN - 1663-4365

VL - 8

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

IS - APR

M1 - 81

ER -

Glial modulation by N-acylethanolamides in brain injury and neurodegeneration

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this