TY - GEN
T1 - Glycolysis as a source of "External Osmoles"
T2 - International Conference on Boundary and Interior Layers - Computational and Asymptotic Methods, BAIL 2008
AU - Hegarty, A. F.
AU - Gonzalez, M.
AU - Thomas, S. R.
PY - 2009
Y1 - 2009
N2 - The kidney is one of the most important organs in our body, responsible for regulating the volume and composition of the extracellular fluid; excreting metabolic waste (as urine) and foreign substances; and also producing some hormones. The mechanisms that contribute to the urine concentrating mechanism are not completely understood. Some ideas have been proposed over the last years and this paper is based on the hypothesis of Thomas (Am J Physiol Renal Physiol 279:468-481, 2000), that glycolysis as a source of external osmoles could contribute to the urine concentrating mechanism. Based on the steady state model developed by Thomas and also on the model developed by Zhang and Edwards (Am J Physiol Renal Physiol 290:87-102, 2005) (a model focused on microcirculation), we have developed a time-dependent modelwhere, besides verifying some of the steady state results of Thomas (Am J Physiol Renal Physiol 279:468-481, 2000), we can also study some time dependent issues, such as the time that it will take to wash out the gradient created by glycolysis if an increase in blood inflow occurs.
AB - The kidney is one of the most important organs in our body, responsible for regulating the volume and composition of the extracellular fluid; excreting metabolic waste (as urine) and foreign substances; and also producing some hormones. The mechanisms that contribute to the urine concentrating mechanism are not completely understood. Some ideas have been proposed over the last years and this paper is based on the hypothesis of Thomas (Am J Physiol Renal Physiol 279:468-481, 2000), that glycolysis as a source of external osmoles could contribute to the urine concentrating mechanism. Based on the steady state model developed by Thomas and also on the model developed by Zhang and Edwards (Am J Physiol Renal Physiol 290:87-102, 2005) (a model focused on microcirculation), we have developed a time-dependent modelwhere, besides verifying some of the steady state results of Thomas (Am J Physiol Renal Physiol 279:468-481, 2000), we can also study some time dependent issues, such as the time that it will take to wash out the gradient created by glycolysis if an increase in blood inflow occurs.
UR - http://www.scopus.com/inward/record.url?scp=78651545824&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-00605-0_11
DO - 10.1007/978-3-642-00605-0_11
M3 - Conference contribution
AN - SCOPUS:78651545824
SN - 9783642006043
T3 - Lecture Notes in Computational Science and Engineering
SP - 153
EP - 161
BT - BAIL 2008 - Boundary and Interior Layers - Proceedings of the International Conference on Boundary and Interior Layers - Computational and Asymptotic Methods
Y2 - 28 July 2008 through 1 August 2008
ER -