Glycolysis as a source of "External Osmoles": The vasa recta transient model

A. F. Hegarty, M. Gonzalez, S. R. Thomas

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The kidney is one of the most important organs in our body, responsible for regulating the volume and composition of the extracellular fluid; excreting metabolic waste (as urine) and foreign substances; and also producing some hormones. The mechanisms that contribute to the urine concentrating mechanism are not completely understood. Some ideas have been proposed over the last years and this paper is based on the hypothesis of Thomas (Am J Physiol Renal Physiol 279:468-481, 2000), that glycolysis as a source of external osmoles could contribute to the urine concentrating mechanism. Based on the steady state model developed by Thomas and also on the model developed by Zhang and Edwards (Am J Physiol Renal Physiol 290:87-102, 2005) (a model focused on microcirculation), we have developed a time-dependent modelwhere, besides verifying some of the steady state results of Thomas (Am J Physiol Renal Physiol 279:468-481, 2000), we can also study some time dependent issues, such as the time that it will take to wash out the gradient created by glycolysis if an increase in blood inflow occurs.

Original languageEnglish
Title of host publicationBAIL 2008 - Boundary and Interior Layers - Proceedings of the International Conference on Boundary and Interior Layers - Computational and Asymptotic Methods
Pages153-161
Number of pages9
DOIs
Publication statusPublished - 2009
EventInternational Conference on Boundary and Interior Layers - Computational and Asymptotic Methods, BAIL 2008 - Limerick, Ireland
Duration: 28 Jul 20081 Aug 2008

Publication series

NameLecture Notes in Computational Science and Engineering
Volume69 LNCSE
ISSN (Print)1439-7358

Conference

ConferenceInternational Conference on Boundary and Interior Layers - Computational and Asymptotic Methods, BAIL 2008
Country/TerritoryIreland
CityLimerick
Period28/07/081/08/08

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