Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells

Charusluk Viphavakit; Sinead O'Keeffe; Stefan Andersson-Engels; Elfed Lewis

doi:10.1109/ICSENS.2017.8234124

Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells

Charusluk Viphavakit, Sinead O'Keeffe, Stefan Andersson-Engels, Elfed Lewis

Department of Electronics & Computer Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

A gold-coated Fabry-Pérot base optical fiber sensor is proposed to measure the oxygen level in hypoxic tumors of prostate cancer through measuring the change of refractive index in red blood cells. The sensors are made entirely of glass with a diameter of 220 μm and few mm long. The tip of the sensors is coated with 100 nm thick gold layer to enhance the interaction between the sensor and hemoglobin in red blood cells. In this paper, pig blood solutions with refractive index values between 1.343 and 1.348 depending on hemoglobin concentration are prepared and analyzed. The phase variation of the output signal which is an interference pattern of the reflected spectrum is measured by taking a Fast Fourier Transform of the reflected signal. A sensitivity of 9.44 rad/RIU can be achieved with a resolution 1.27∗10^-3 RIU for this sensor.

Original language	English
Title of host publication	IEEE SENSORS 2017 - Conference Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1-3
Number of pages	3
ISBN (Electronic)	9781509010127
DOIs	https://doi.org/10.1109/ICSENS.2017.8234124
Publication status	Published - 21 Dec 2017
Event	16th IEEE SENSORS Conference, ICSENS 2017 - Glasgow, United Kingdom Duration: 30 Oct 2017 → 1 Nov 2017

Publication series

Name	Proceedings of IEEE Sensors
Volume	2017-December
ISSN (Print)	1930-0395
ISSN (Electronic)	2168-9229

Conference

Conference	16th IEEE SENSORS Conference, ICSENS 2017
Country/Territory	United Kingdom
City	Glasgow
Period	30/10/17 → 1/11/17

Keywords

Fabry-Pérot interferometer
hypoxic tumors
Optical fiber sensor
refractive index sensing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/ICSENS.2017.8234124

Cite this

Viphavakit, C., O'Keeffe, S., Andersson-Engels, S., & Lewis, E. (2017). Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells. In IEEE SENSORS 2017 - Conference Proceedings (pp. 1-3). (Proceedings of IEEE Sensors; Vol. 2017-December). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICSENS.2017.8234124

Viphavakit, Charusluk ; O'Keeffe, Sinead ; Andersson-Engels, Stefan et al. / Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells. IEEE SENSORS 2017 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 1-3 (Proceedings of IEEE Sensors).

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title = "Gold-coated Fabry-P{\'e}rot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells",

abstract = "A gold-coated Fabry-P{\'e}rot base optical fiber sensor is proposed to measure the oxygen level in hypoxic tumors of prostate cancer through measuring the change of refractive index in red blood cells. The sensors are made entirely of glass with a diameter of 220 μm and few mm long. The tip of the sensors is coated with 100 nm thick gold layer to enhance the interaction between the sensor and hemoglobin in red blood cells. In this paper, pig blood solutions with refractive index values between 1.343 and 1.348 depending on hemoglobin concentration are prepared and analyzed. The phase variation of the output signal which is an interference pattern of the reflected spectrum is measured by taking a Fast Fourier Transform of the reflected signal. A sensitivity of 9.44 rad/RIU can be achieved with a resolution 1.27∗10-3 RIU for this sensor.",

keywords = "Fabry-P{\'e}rot interferometer, hypoxic tumors, Optical fiber sensor, refractive index sensing",

author = "Charusluk Viphavakit and Sinead O'Keeffe and Stefan Andersson-Engels and Elfed Lewis",

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Viphavakit, C, O'Keeffe, S, Andersson-Engels, S & Lewis, E 2017, Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells. in IEEE SENSORS 2017 - Conference Proceedings. Proceedings of IEEE Sensors, vol. 2017-December, Institute of Electrical and Electronics Engineers Inc., pp. 1-3, 16th IEEE SENSORS Conference, ICSENS 2017, Glasgow, United Kingdom, 30/10/17. https://doi.org/10.1109/ICSENS.2017.8234124

Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells. / Viphavakit, Charusluk; O'Keeffe, Sinead; Andersson-Engels, Stefan et al.
IEEE SENSORS 2017 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. p. 1-3 (Proceedings of IEEE Sensors; Vol. 2017-December).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Lewis, Elfed

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AB - A gold-coated Fabry-Pérot base optical fiber sensor is proposed to measure the oxygen level in hypoxic tumors of prostate cancer through measuring the change of refractive index in red blood cells. The sensors are made entirely of glass with a diameter of 220 μm and few mm long. The tip of the sensors is coated with 100 nm thick gold layer to enhance the interaction between the sensor and hemoglobin in red blood cells. In this paper, pig blood solutions with refractive index values between 1.343 and 1.348 depending on hemoglobin concentration are prepared and analyzed. The phase variation of the output signal which is an interference pattern of the reflected spectrum is measured by taking a Fast Fourier Transform of the reflected signal. A sensitivity of 9.44 rad/RIU can be achieved with a resolution 1.27∗10-3 RIU for this sensor.

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Viphavakit C, O'Keeffe S, Andersson-Engels S, Lewis E. Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells. In IEEE SENSORS 2017 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1-3. (Proceedings of IEEE Sensors). doi: 10.1109/ICSENS.2017.8234124

Gold-coated Fabry-Pérot based optical fiber sensor for monitoring hypoxic state of the tumor from the change of refractive index in red blood cells

Abstract

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Keywords

UN SDGs

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