TY - JOUR
T1 - Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation
AU - Wang, Dongxu
AU - Gao, Qiang
AU - Wang, Taotao
AU - Kan, Zhipeng
AU - Li, Xin
AU - Hu, Lizhen
AU - Peng, Chuan yi
AU - Qian, Frank
AU - Wang, Yijun
AU - Granato, Daniel
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1
Y1 - 2020/1
N2 - Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.
AB - Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.
KW - EGCG
KW - Functional foods
KW - Green tea polyphenols
KW - In vivo study
KW - NLRP3 inflammasome
KW - Oxidative stress
KW - Perfluorodecanoic acid
KW - Tea catechins
UR - http://www.scopus.com/inward/record.url?scp=85071697238&partnerID=8YFLogxK
U2 - 10.1016/j.foodres.2019.108628
DO - 10.1016/j.foodres.2019.108628
M3 - Article
C2 - 31882076
AN - SCOPUS:85071697238
SN - 0963-9969
VL - 127
SP - 108628
JO - Food Research International
JF - Food Research International
M1 - 108628
ER -