Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

Dongxu Wang; Qiang Gao; Taotao Wang; Zhipeng Kan; Xin Li; Lizhen Hu; Chuan yi Peng; Frank Qian; Yijun Wang; Daniel Granato

doi:10.1016/j.foodres.2019.108628

Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

Dongxu Wang
, Qiang Gao
, Taotao Wang
, Zhipeng Kan
, Xin Li
, Lizhen Hu
, Chuan yi Peng
, Frank Qian
, Yijun Wang
, Daniel Granato

Anhui Agricultural University
Jiangsu University
The University of Chicago
Luke Natural Resources Institute Finland

Research output: Contribution to journal › Article › peer-review

Abstract

Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.

Original language	English
Article number	108628
Journal	Food Research International
Volume	127
DOIs	https://doi.org/10.1016/j.foodres.2019.108628
Publication status	Published - Jan 2020
Externally published	Yes

Keywords

EGCG
Functional foods
Green tea polyphenols
In vivo study
NLRP3 inflammasome
Oxidative stress
Perfluorodecanoic acid
Tea catechins

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10.1016/j.foodres.2019.108628

Cite this

Wang, D., Gao, Q., Wang, T., Kan, Z., Li, X., Hu, L., Peng, C. Y., Qian, F., Wang, Y., & Granato, D. (2020). Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation. Food Research International, 127, Article 108628. https://doi.org/10.1016/j.foodres.2019.108628

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title = "Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation",

abstract = "Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32\%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.",

keywords = "EGCG, Functional foods, Green tea polyphenols, In vivo study, NLRP3 inflammasome, Oxidative stress, Perfluorodecanoic acid, Tea catechins",

author = "Dongxu Wang and Qiang Gao and Taotao Wang and Zhipeng Kan and Xin Li and Lizhen Hu and Peng, \{Chuan yi\} and Frank Qian and Yijun Wang and Daniel Granato",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = jan,

doi = "10.1016/j.foodres.2019.108628",

language = "English",

volume = "127",

journal = "Food Research International",

issn = "0963-9969",

}

Wang, D, Gao, Q, Wang, T, Kan, Z, Li, X, Hu, L, Peng, CY, Qian, F, Wang, Y & Granato, D 2020, 'Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation', Food Research International, vol. 127, 108628. https://doi.org/10.1016/j.foodres.2019.108628

TY - JOUR

T1 - Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

AU - Wang, Dongxu

AU - Gao, Qiang

AU - Wang, Taotao

AU - Kan, Zhipeng

AU - Li, Xin

AU - Hu, Lizhen

AU - Peng, Chuan yi

AU - Qian, Frank

AU - Wang, Yijun

AU - Granato, Daniel

PY - 2020/1

Y1 - 2020/1

N2 - Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.

AB - Perfluorodecanoic acid (PFDA) is a highly toxic food contaminant that is extensively used in food applications as surface antifouling agent. In this present study, we aimed to assess whether green tea polyphenols (GTPs) and epigallocatechin-3-gallate (EGCG) exert protective effects against PFDA-induced liver damage and inflammation in mice. A mouse model to evaluate liver toxicity was established by giving mice drinking water containing different concentrations of PFDA. GTPs or EGCG (0.32%, w/v) were co-administered to mice exposed to PFDA in drinking water. Overall, GTPs and EGCG extended the survival time and inhibited weight loss among mice who received a lower dose of PFDA. Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA. Taken together, these results show that GTPs or EGCG (or green tea intake) supplements can be beneficial for people exposed to PFDA.

KW - EGCG

KW - Functional foods

KW - Green tea polyphenols

KW - In vivo study

KW - NLRP3 inflammasome

KW - Oxidative stress

KW - Perfluorodecanoic acid

KW - Tea catechins

UR - https://www.scopus.com/pages/publications/85071697238

U2 - 10.1016/j.foodres.2019.108628

DO - 10.1016/j.foodres.2019.108628

M3 - Article

C2 - 31882076

AN - SCOPUS:85071697238

SN - 0963-9969

VL - 127

JO - Food Research International

JF - Food Research International

M1 - 108628

ER -

Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation

Abstract

Keywords

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