Ground State and Excited-State Electron Transfer Reactions of Zinc Cytochrome c

Edmond Magner; George McLendon

doi:10.1021/j100357a021

Ground State and Excited-State Electron Transfer Reactions of Zinc Cytochrome c

Edmond Magner, George McLendon

Department of Chemical Sciences

University of Rochester

Research output: Contribution to journal › Article › peer-review

Abstract

Zinc-substituted cytochrome c, Zn cyt c, in which the heme iron atom is substituted by Zn(II), has been used in a number of basic studies of electron-transfer reactions of proteins. In this paper we report detailed studies of the ground-state and excited-state redox behavior of Zn cyt c which provide experimental estimates of key parameters including the oxidation potential (Zn cyt c)/Zn c, E° ≅ 0.8 V, and the (relative) reaction rates of Zn cyt c/Fe cyt c with a common reactant (corrected for reaction ΔG), k₁₁(Zn)/k₁₁(Fe) = 5 ± 1. The implications of these results for electron-transfer studies of proteins are briefly discussed.

Original language	English (Ireland)
Pages (from-to)	7130-7134
Number of pages	5
Journal	Journal of Physical Chemistry
Volume	93
Issue number	20
DOIs	https://doi.org/10.1021/j100357a021
Publication status	Published - 1989

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abstract = "Zinc-substituted cytochrome c, Zn cyt c, in which the heme iron atom is substituted by Zn(II), has been used in a number of basic studies of electron-transfer reactions of proteins. In this paper we report detailed studies of the ground-state and excited-state redox behavior of Zn cyt c which provide experimental estimates of key parameters including the oxidation potential (Zn cyt c)/Zn c, E° ≅ 0.8 V, and the (relative) reaction rates of Zn cyt c/Fe cyt c with a common reactant (corrected for reaction ΔG), k11(Zn)/k11(Fe) = 5 ± 1. The implications of these results for electron-transfer studies of proteins are briefly discussed.",

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journal = "Journal of Physical Chemistry",

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T1 - Ground State and Excited-State Electron Transfer Reactions of Zinc Cytochrome c

AU - Magner, Edmond

AU - McLendon, George

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N2 - Zinc-substituted cytochrome c, Zn cyt c, in which the heme iron atom is substituted by Zn(II), has been used in a number of basic studies of electron-transfer reactions of proteins. In this paper we report detailed studies of the ground-state and excited-state redox behavior of Zn cyt c which provide experimental estimates of key parameters including the oxidation potential (Zn cyt c)/Zn c, E° ≅ 0.8 V, and the (relative) reaction rates of Zn cyt c/Fe cyt c with a common reactant (corrected for reaction ΔG), k11(Zn)/k11(Fe) = 5 ± 1. The implications of these results for electron-transfer studies of proteins are briefly discussed.

AB - Zinc-substituted cytochrome c, Zn cyt c, in which the heme iron atom is substituted by Zn(II), has been used in a number of basic studies of electron-transfer reactions of proteins. In this paper we report detailed studies of the ground-state and excited-state redox behavior of Zn cyt c which provide experimental estimates of key parameters including the oxidation potential (Zn cyt c)/Zn c, E° ≅ 0.8 V, and the (relative) reaction rates of Zn cyt c/Fe cyt c with a common reactant (corrected for reaction ΔG), k11(Zn)/k11(Fe) = 5 ± 1. The implications of these results for electron-transfer studies of proteins are briefly discussed.

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DO - 10.1021/j100357a021

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SP - 7130

EP - 7134

JO - Journal of Physical Chemistry

JF - Journal of Physical Chemistry

IS - 20

ER -

Ground State and Excited-State Electron Transfer Reactions of Zinc Cytochrome c

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