TY - JOUR
T1 - Guest Diffusion Versus Recrystallization in A Single Crystal
T2 - Two Growing Mechanisms for Griseofulvin Clathrates
AU - Spoletti, Enrico
AU - Diniz, Mariana O.
AU - Svärd, Michael
AU - Rasmuson, Åke
AU - Hudson, Sarah P.
AU - Lusi, Matteo
N1 - Publisher Copyright:
© 2024 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH.
PY - 2024
Y1 - 2024
N2 - Griseofulvin represents a rare case of a close-packed organic apohost that can clathrate selected volatile guests in a solid-gas fashion. Inclusion mechanisms and solvent exchange were investigated by a combination of single crystal and powder X-ray diffraction, coupled to optical microscopy and thermal analyses. In particular, gas diffusion and dissolution/recrystallization are alternatively observed, depending on the host polymorph, as well as the chemical nature of the guest and its physical state.
AB - Griseofulvin represents a rare case of a close-packed organic apohost that can clathrate selected volatile guests in a solid-gas fashion. Inclusion mechanisms and solvent exchange were investigated by a combination of single crystal and powder X-ray diffraction, coupled to optical microscopy and thermal analyses. In particular, gas diffusion and dissolution/recrystallization are alternatively observed, depending on the host polymorph, as well as the chemical nature of the guest and its physical state.
KW - Flexible organic structure
KW - Griseofulvin
KW - Organic inclusion compound
KW - Single crystal to single crystal transformation
KW - Solid-vapor sorption
UR - http://www.scopus.com/inward/record.url?scp=85213306233&partnerID=8YFLogxK
U2 - 10.1002/chem.202403488
DO - 10.1002/chem.202403488
M3 - Article
AN - SCOPUS:85213306233
SN - 0947-6539
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
ER -