TY - JOUR
T1 - Gut microbiota composition correlates with diet and health in the elderly
AU - Claesson, Marcus J.
AU - Jeffery, Ian B.
AU - Conde, Susana
AU - Power, Susan E.
AU - O'connor, Eibhlís M.
AU - Cusack, Siobhán
AU - Harris, Hugh M.B.
AU - Coakley, Mairead
AU - Lakshminarayanan, Bhuvaneswari
AU - O'sullivan, Orla
AU - Fitzgerald, Gerald F.
AU - Deane, Jennifer
AU - O'connor, Michael
AU - Harnedy, Norma
AU - O'connor, Kieran
AU - O'mahony, Denis
AU - Van Sinderen, Douwe
AU - Wallace, Martina
AU - Brennan, Lorraine
AU - Stanton, Catherine
AU - Marchesi, Julian R.
AU - Fitzgerald, Anthony P.
AU - Shanahan, Fergus
AU - Hill, Colin
AU - Paul Ross, R.
AU - O'toole, Paul W.
PY - 2012/8/9
Y1 - 2012/8/9
N2 - Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
AB - Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
UR - http://www.scopus.com/inward/record.url?scp=84864722033&partnerID=8YFLogxK
U2 - 10.1038/nature11319
DO - 10.1038/nature11319
M3 - Article
C2 - 22797518
AN - SCOPUS:84864722033
SN - 0028-0836
VL - 488
SP - 178
EP - 184
JO - Nature
JF - Nature
IS - 7410
ER -