Hygroscopicity of lithium coordination polymers and their solid solutions

Monica Lestari; Matteo Lusi; Aoife O'Leary; Daniel O'Nolan; Michael J. Zaworotko

doi:10.1039/c8ce00905h

Hygroscopicity of lithium coordination polymers and their solid solutions

Monica Lestari, Matteo Lusi, Aoife O'Leary, Daniel O'Nolan, Michael J. Zaworotko

Department of Chemical Sciences

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

Coordination polymers (CPs) of active pharmaceutical ingredients (APIs) are relatively rare, though recent studies show how these forms can afford improved solubility and stability. Here, the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their potential utility as drug substances. In particular, the solid solutions of {[(PRO)Li(MBNZ)_1-x(BNZ)_x]}_n (1_x) show lower stability than both the pure compounds whereas in the solid solutions of {[Li₂(SUC)_1-x(MAL)_x]}_n (2_x), the hygroscopicity varies more regularly with composition.

Original language	English
Pages (from-to)	5940-5944
Number of pages	5
Journal	CrystEngComm
Volume	20
Issue number	39
DOIs	https://doi.org/10.1039/c8ce00905h
Publication status	Published - 2018

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title = "Hygroscopicity of lithium coordination polymers and their solid solutions",

abstract = "Coordination polymers (CPs) of active pharmaceutical ingredients (APIs) are relatively rare, though recent studies show how these forms can afford improved solubility and stability. Here, the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their potential utility as drug substances. In particular, the solid solutions of {[(PRO)Li(MBNZ)1-x(BNZ)x]}n (1x) show lower stability than both the pure compounds whereas in the solid solutions of {[Li2(SUC)1-x(MAL)x]}n (2x), the hygroscopicity varies more regularly with composition.",

author = "Monica Lestari and Matteo Lusi and Aoife O'Leary and Daniel O'Nolan and Zaworotko, {Michael J.}",

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AU - Lestari, Monica

AU - Lusi, Matteo

AU - O'Leary, Aoife

AU - O'Nolan, Daniel

AU - Zaworotko, Michael J.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2018.

PY - 2018

Y1 - 2018

N2 - Coordination polymers (CPs) of active pharmaceutical ingredients (APIs) are relatively rare, though recent studies show how these forms can afford improved solubility and stability. Here, the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their potential utility as drug substances. In particular, the solid solutions of {[(PRO)Li(MBNZ)1-x(BNZ)x]}n (1x) show lower stability than both the pure compounds whereas in the solid solutions of {[Li2(SUC)1-x(MAL)x]}n (2x), the hygroscopicity varies more regularly with composition.

AB - Coordination polymers (CPs) of active pharmaceutical ingredients (APIs) are relatively rare, though recent studies show how these forms can afford improved solubility and stability. Here, the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their potential utility as drug substances. In particular, the solid solutions of {[(PRO)Li(MBNZ)1-x(BNZ)x]}n (1x) show lower stability than both the pure compounds whereas in the solid solutions of {[Li2(SUC)1-x(MAL)x]}n (2x), the hygroscopicity varies more regularly with composition.

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Hygroscopicity of lithium coordination polymers and their solid solutions

Abstract

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