Improving mixing in microbioreactors

X. Li, G. van der Steen, G. W.K. van Dedem, L. A.M. van der Wielen, M. van Leeuwen, W. M. van Gulik, J. J. Heijnen, E. E. Krommenhoek, J. G.E. Gardeniers, A. van den Berg, M. Ottens

Research output: Contribution to journalArticlepeer-review

Abstract

This paper describes a possible active mixing method for a 30 μ l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior.

Original languageEnglish
Pages (from-to)3036-3046
Number of pages11
JournalChemical Engineering Science
Volume63
Issue number11
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Keywords

  • Computational fluid dynamics (CFD)
  • Microbioreactor
  • Microfluidics
  • Micromixing
  • Rayleigh-Bénard convection
  • Recycle flow mixing

Fingerprint

Dive into the research topics of 'Improving mixing in microbioreactors'. Together they form a unique fingerprint.

Cite this