Improving mixing in microbioreactors

X. Li; G. van der Steen; G. W.K. van Dedem; L. A.M. van der Wielen; M. van Leeuwen; W. M. van Gulik; J. J. Heijnen; E. E. Krommenhoek; J. G.E. Gardeniers; A. van den Berg; M. Ottens

doi:10.1016/j.ces.2008.02.036

Improving mixing in microbioreactors

X. Li
, G. van der Steen
, G. W.K. van Dedem
, L. A.M. van der Wielen
, M. van Leeuwen
, W. M. van Gulik
, J. J. Heijnen
, E. E. Krommenhoek
, J. G.E. Gardeniers
, A. van den Berg
, M. Ottens

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes a possible active mixing method for a 30 μ l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior.

Original language	English
Pages (from-to)	3036-3046
Number of pages	11
Journal	Chemical Engineering Science
Volume	63
Issue number	11
DOIs	https://doi.org/10.1016/j.ces.2008.02.036
Publication status	Published - Jun 2008
Externally published	Yes

Keywords

Computational fluid dynamics (CFD)
Microbioreactor
Microfluidics
Micromixing
Rayleigh-Bénard convection
Recycle flow mixing

Access to Document

10.1016/j.ces.2008.02.036

Cite this

@article{216a4bd54e5248828250f194e58919ff,

title = "Improving mixing in microbioreactors",

abstract = "This paper describes a possible active mixing method for a 30 μ l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior.",

keywords = "Computational fluid dynamics (CFD), Microbioreactor, Microfluidics, Micromixing, Rayleigh-B{\'e}nard convection, Recycle flow mixing",

author = "X. Li and \{van der Steen\}, G. and \{van Dedem\}, \{G. W.K.\} and \{van der Wielen\}, \{L. A.M.\} and \{van Leeuwen\}, M. and \{van Gulik\}, \{W. M.\} and Heijnen, \{J. J.\} and Krommenhoek, \{E. E.\} and Gardeniers, \{J. G.E.\} and \{van den Berg\}, A. and M. Ottens",

year = "2008",

month = jun,

doi = "10.1016/j.ces.2008.02.036",

language = "English",

volume = "63",

pages = "3036--3046",

journal = "Chemical Engineering Science",

issn = "0009-2509",

number = "11",

}

TY - JOUR

T1 - Improving mixing in microbioreactors

AU - Li, X.

AU - van der Steen, G.

AU - van Dedem, G. W.K.

AU - van der Wielen, L. A.M.

AU - van Leeuwen, M.

AU - van Gulik, W. M.

AU - Heijnen, J. J.

AU - Krommenhoek, E. E.

AU - Gardeniers, J. G.E.

AU - van den Berg, A.

AU - Ottens, M.

PY - 2008/6

Y1 - 2008/6

N2 - This paper describes a possible active mixing method for a 30 μ l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior.

AB - This paper describes a possible active mixing method for a 30 μ l microbioreactor that was designed, simulated and tested. Pressure based recycle flow was investigated in a cylindrical microreactor for mixing efficiency. Based on the computational fluid dynamics (CFD) simulation results and the requirements of the application, the recycle flow mixing method proved to be suitable as a method to induce sufficient mixing in the microbioreactor. This was verified experimentally using image analysis of dye distribution behavior.

KW - Computational fluid dynamics (CFD)

KW - Microbioreactor

KW - Microfluidics

KW - Micromixing

KW - Rayleigh-Bénard convection

KW - Recycle flow mixing

UR - https://www.scopus.com/pages/publications/43049183185

U2 - 10.1016/j.ces.2008.02.036

DO - 10.1016/j.ces.2008.02.036

M3 - Article

AN - SCOPUS:43049183185

SN - 0009-2509

VL - 63

SP - 3036

EP - 3046

JO - Chemical Engineering Science

JF - Chemical Engineering Science

IS - 11

ER -

Improving mixing in microbioreactors

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this