Impurity effects on the crystallization kinetics of ampicillin

M. Ottens; B. Lebreton; M. Zomerdijk; M. P.W.M. Rijkers; O. S.L. Bruinsma; L. A.M. Van Der Wielen

doi:10.1021/ie0307028

Impurity effects on the crystallization kinetics of ampicillin

M. Ottens, B. Lebreton, M. Zomerdijk, M. P.W.M. Rijkers, O. S.L. Bruinsma, L. A.M. Van Der Wielen

Research output: Contribution to journal › Article › peer-review

Abstract

Impurities have a clear negative influence on the nucleation and growth rate kinetics of the semisynthetic antibiotic ampicillin (AMPI) crystallization. The tested impurities phenylglycine and 6-aminopenicillanic acid are the building blocks of AMPI and will therefore be present in any AMPI manufacturing process, as well as the tested AMPI degradation products. The negative impact increases with an increase in the impurity concentration. This is shown by an increase in the induction time of crystallization measured and reported in this paper. The growth rate G (m s^-1) is related to the supersaturation ratio S of AMPI. The growth rate is determined with a previously developed adapted single-crystal growth rate analysis method (Ottens, M.; et al. Ind. Eng. Chem. Res. 2001, 40, 4821-4827). The mechanism for retardation of the crystallization process is argued to be the blocking of the crystal surface by the impurities.

Original language	English
Pages (from-to)	7932-7938
Number of pages	7
Journal	Industrial and Engineering Chemistry Research
Volume	43
Issue number	24
DOIs	https://doi.org/10.1021/ie0307028
Publication status	Published - 24 Nov 2004
Externally published	Yes

Access to Document

10.1021/ie0307028

Cite this

@article{a27b146f97f64bc08184d23ca2973aa1,

title = "Impurity effects on the crystallization kinetics of ampicillin",

abstract = "Impurities have a clear negative influence on the nucleation and growth rate kinetics of the semisynthetic antibiotic ampicillin (AMPI) crystallization. The tested impurities phenylglycine and 6-aminopenicillanic acid are the building blocks of AMPI and will therefore be present in any AMPI manufacturing process, as well as the tested AMPI degradation products. The negative impact increases with an increase in the impurity concentration. This is shown by an increase in the induction time of crystallization measured and reported in this paper. The growth rate G (m s-1) is related to the supersaturation ratio S of AMPI. The growth rate is determined with a previously developed adapted single-crystal growth rate analysis method (Ottens, M.; et al. Ind. Eng. Chem. Res. 2001, 40, 4821-4827). The mechanism for retardation of the crystallization process is argued to be the blocking of the crystal surface by the impurities.",

author = "M. Ottens and B. Lebreton and M. Zomerdijk and Rijkers, {M. P.W.M.} and Bruinsma, {O. S.L.} and {Van Der Wielen}, {L. A.M.}",

year = "2004",

month = nov,

day = "24",

doi = "10.1021/ie0307028",

language = "English",

volume = "43",

pages = "7932--7938",

journal = "Industrial and Engineering Chemistry Research",

issn = "0888-5885",

number = "24",

}

TY - JOUR

T1 - Impurity effects on the crystallization kinetics of ampicillin

AU - Ottens, M.

AU - Lebreton, B.

AU - Zomerdijk, M.

AU - Rijkers, M. P.W.M.

AU - Bruinsma, O. S.L.

AU - Van Der Wielen, L. A.M.

PY - 2004/11/24

Y1 - 2004/11/24

N2 - Impurities have a clear negative influence on the nucleation and growth rate kinetics of the semisynthetic antibiotic ampicillin (AMPI) crystallization. The tested impurities phenylglycine and 6-aminopenicillanic acid are the building blocks of AMPI and will therefore be present in any AMPI manufacturing process, as well as the tested AMPI degradation products. The negative impact increases with an increase in the impurity concentration. This is shown by an increase in the induction time of crystallization measured and reported in this paper. The growth rate G (m s-1) is related to the supersaturation ratio S of AMPI. The growth rate is determined with a previously developed adapted single-crystal growth rate analysis method (Ottens, M.; et al. Ind. Eng. Chem. Res. 2001, 40, 4821-4827). The mechanism for retardation of the crystallization process is argued to be the blocking of the crystal surface by the impurities.

AB - Impurities have a clear negative influence on the nucleation and growth rate kinetics of the semisynthetic antibiotic ampicillin (AMPI) crystallization. The tested impurities phenylglycine and 6-aminopenicillanic acid are the building blocks of AMPI and will therefore be present in any AMPI manufacturing process, as well as the tested AMPI degradation products. The negative impact increases with an increase in the impurity concentration. This is shown by an increase in the induction time of crystallization measured and reported in this paper. The growth rate G (m s-1) is related to the supersaturation ratio S of AMPI. The growth rate is determined with a previously developed adapted single-crystal growth rate analysis method (Ottens, M.; et al. Ind. Eng. Chem. Res. 2001, 40, 4821-4827). The mechanism for retardation of the crystallization process is argued to be the blocking of the crystal surface by the impurities.

UR - http://www.scopus.com/inward/record.url?scp=9244244239&partnerID=8YFLogxK

U2 - 10.1021/ie0307028

DO - 10.1021/ie0307028

M3 - Article

AN - SCOPUS:9244244239

SN - 0888-5885

VL - 43

SP - 7932

EP - 7938

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

IS - 24

ER -

Impurity effects on the crystallization kinetics of ampicillin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this