In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas

P. G. Murray; G. Niedobitek; E. Kremmer; F. Grässer; G. M. Reynolds; A. Cruchley; D. M. Williams; N. Müller-Lantzsch; L. S. Young

doi:10.1002/(SICI)1096-9896(199601)178:1<44::AID-PATH471>3.0.CO;2-0

In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas

P. G. Murray, G. Niedobitek, E. Kremmer, F. Grässer, G. M. Reynolds, A. Cruchley, D. M. Williams, N. Müller-Lantzsch, L. S. Young

Research output: Contribution to journal › Article › peer-review

Abstract

A new monoclonal antibody has been used to examine immunohistochemically the expression of the Epstein-Barr virus (EBV)-encoded nuclear antigen (EBNA) 1 in virus-associated epithelial lesions. EBNA1 was detected in the tumour cell nuclei of 10/13 undifferentiated nasopharyngeal carcinomas and of 10/10 EBV-associated gastric carcinomas. EBNA1 was also detected in 13 of 16 oral hairy leukoplakia (HL) samples, where its expression was confined to nuclei in the upper epithelial cell layers whilst basal epithelial cells were negative. This observation is in agreement with previous studies demonstrating the absence of latent EBV infection in the basal cell compartment of HL and suggests an essential role for EBNA1, not only in latent EBV infection but also in virus replication.

Original language	English
Pages (from-to)	44-47
Number of pages	4
Journal	The Journal of Pathology
Volume	178
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1096-9896(199601)178:1<44::AID-PATH471>3.0.CO;2-0
Publication status	Published - 1996
Externally published	Yes

Keywords

EBNA1
EBV
Gastric carcinoma
Hairy leukoplakia
Nasopharyngeal carcinoma

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(SICI)1096-9896(199601)178:1<44::AID-PATH471>3.0.CO;2-0

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Murray, P. G., Niedobitek, G., Kremmer, E., Grässer, F., Reynolds, G. M., Cruchley, A., Williams, D. M., Müller-Lantzsch, N., & Young, L. S. (1996). In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas. The Journal of Pathology, 178(1), 44-47. https://doi.org/10.1002/(SICI)1096-9896(199601)178:1<44::AID-PATH471>3.0.CO;2-0

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title = "In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas",

abstract = "A new monoclonal antibody has been used to examine immunohistochemically the expression of the Epstein-Barr virus (EBV)-encoded nuclear antigen (EBNA) 1 in virus-associated epithelial lesions. EBNA1 was detected in the tumour cell nuclei of 10/13 undifferentiated nasopharyngeal carcinomas and of 10/10 EBV-associated gastric carcinomas. EBNA1 was also detected in 13 of 16 oral hairy leukoplakia (HL) samples, where its expression was confined to nuclei in the upper epithelial cell layers whilst basal epithelial cells were negative. This observation is in agreement with previous studies demonstrating the absence of latent EBV infection in the basal cell compartment of HL and suggests an essential role for EBNA1, not only in latent EBV infection but also in virus replication.",

keywords = "EBNA1, EBV, Gastric carcinoma, Hairy leukoplakia, Nasopharyngeal carcinoma",

author = "Murray, {P. G.} and G. Niedobitek and E. Kremmer and F. Gr{\"a}sser and Reynolds, {G. M.} and A. Cruchley and Williams, {D. M.} and N. M{\"u}ller-Lantzsch and Young, {L. S.}",

year = "1996",

doi = "10.1002/(SICI)1096-9896(199601)178:1<44::AID-PATH471>3.0.CO;2-0",

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Murray, PG, Niedobitek, G, Kremmer, E, Grässer, F, Reynolds, GM, Cruchley, A, Williams, DM, Müller-Lantzsch, N & Young, LS 1996, 'In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas', The Journal of Pathology, vol. 178, no. 1, pp. 44-47. https://doi.org/10.1002/(SICI)1096-9896(199601)178:1<44::AID-PATH471>3.0.CO;2-0

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T1 - In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas

AU - Murray, P. G.

AU - Niedobitek, G.

AU - Kremmer, E.

AU - Grässer, F.

AU - Reynolds, G. M.

AU - Cruchley, A.

AU - Williams, D. M.

AU - Müller-Lantzsch, N.

AU - Young, L. S.

PY - 1996

Y1 - 1996

N2 - A new monoclonal antibody has been used to examine immunohistochemically the expression of the Epstein-Barr virus (EBV)-encoded nuclear antigen (EBNA) 1 in virus-associated epithelial lesions. EBNA1 was detected in the tumour cell nuclei of 10/13 undifferentiated nasopharyngeal carcinomas and of 10/10 EBV-associated gastric carcinomas. EBNA1 was also detected in 13 of 16 oral hairy leukoplakia (HL) samples, where its expression was confined to nuclei in the upper epithelial cell layers whilst basal epithelial cells were negative. This observation is in agreement with previous studies demonstrating the absence of latent EBV infection in the basal cell compartment of HL and suggests an essential role for EBNA1, not only in latent EBV infection but also in virus replication.

AB - A new monoclonal antibody has been used to examine immunohistochemically the expression of the Epstein-Barr virus (EBV)-encoded nuclear antigen (EBNA) 1 in virus-associated epithelial lesions. EBNA1 was detected in the tumour cell nuclei of 10/13 undifferentiated nasopharyngeal carcinomas and of 10/10 EBV-associated gastric carcinomas. EBNA1 was also detected in 13 of 16 oral hairy leukoplakia (HL) samples, where its expression was confined to nuclei in the upper epithelial cell layers whilst basal epithelial cells were negative. This observation is in agreement with previous studies demonstrating the absence of latent EBV infection in the basal cell compartment of HL and suggests an essential role for EBNA1, not only in latent EBV infection but also in virus replication.

KW - EBNA1

KW - EBV

KW - Gastric carcinoma

KW - Hairy leukoplakia

KW - Nasopharyngeal carcinoma

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In situ detection of the Epstein-Barr virus-encoded nuclear antigen 1 in oral hairy leukoplakia and virus-associated carcinomas

Abstract

Keywords

UN SDGs

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