TY - JOUR
T1 - In situ synthesis of a functional ZIF-8 nanocomposite for synergistic photodynamic-chemotherapy and pH and NIR-stimulated drug release
AU - Wen, Xin
AU - Liu, Ning
AU - Ren, Jia
AU - Jiao, Xiaorui
AU - Lv, Junying
AU - Akhtar, Mahmood Hassan
AU - Qi, Hong
AU - Zhu, Jianwei
AU - Yu, Cong
AU - Li, Yunhui
N1 - Publisher Copyright:
© 2022 The Royal Society of Chemistry
PY - 2022/3/10
Y1 - 2022/3/10
N2 - In this paper, we designed and synthesized a novel pH and NIR light responsive UCNP/TiO2/Cur@ZIF-8 nano-composite. The newly synthesized nano-platform was characterized using spectroscopic methods. Here, upconversion nanoparticles (UCNPs) and titanium dioxide nanoparticles (TiO2 NPs) were encapsulated to upconvert energy through the photosensitizing phenomenon where the chemotherapeutic agent curcumin (Cur) and TiO2 synergistically achieved therapeutic effects. At first, ZIF-8 decomposed in the acidic microenvironment of tumors that assisted TiO2 NPs to efficiently convert the irradiated near infrared (NIR) 808 nm light into UV visible light, thus producing a large number of reactive oxygen species to effectively inhibit tumor growth. Furthermore, in vitro and in vivo data demonstrated that UCNP/TiO2/Cur@ZIF-8 is an excellent nanoplatform that can be used as NIR-mediated photodynamic as well as chemotherapeutic therapy for tumors.
AB - In this paper, we designed and synthesized a novel pH and NIR light responsive UCNP/TiO2/Cur@ZIF-8 nano-composite. The newly synthesized nano-platform was characterized using spectroscopic methods. Here, upconversion nanoparticles (UCNPs) and titanium dioxide nanoparticles (TiO2 NPs) were encapsulated to upconvert energy through the photosensitizing phenomenon where the chemotherapeutic agent curcumin (Cur) and TiO2 synergistically achieved therapeutic effects. At first, ZIF-8 decomposed in the acidic microenvironment of tumors that assisted TiO2 NPs to efficiently convert the irradiated near infrared (NIR) 808 nm light into UV visible light, thus producing a large number of reactive oxygen species to effectively inhibit tumor growth. Furthermore, in vitro and in vivo data demonstrated that UCNP/TiO2/Cur@ZIF-8 is an excellent nanoplatform that can be used as NIR-mediated photodynamic as well as chemotherapeutic therapy for tumors.
UR - http://www.scopus.com/inward/record.url?scp=85128124212&partnerID=8YFLogxK
U2 - 10.1039/d2nj00082b
DO - 10.1039/d2nj00082b
M3 - Article
AN - SCOPUS:85128124212
SN - 1144-0546
VL - 46
SP - 6966
EP - 6970
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 15
ER -
