In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds

Eleni Sioriki; Ronan Lordan; Fady Nahra; Kristof van Hecke; Ioannis Zabetakis; Steven P. Nolan

doi:10.1002/cmdc.201800601

In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds

Eleni Sioriki
, Ronan Lordan
, Fady Nahra
, Kristof van Hecke
, Ioannis Zabetakis
, Steven P. Nolan

Department of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl₂] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl₂] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.

Original language	English
Pages (from-to)	2484-2487
Number of pages	4
Journal	ChemMedChem
Volume	13
Issue number	23
DOIs	https://doi.org/10.1002/cmdc.201800601
Publication status	Published - 6 Dec 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anti-atherogenic activity
atheromatosis
aurates
N-heterocyclic carbenes
platelet-activating factor

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10.1002/cmdc.201800601

Cite this

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title = "In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds",

abstract = "The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.",

keywords = "anti-atherogenic activity, atheromatosis, aurates, N-heterocyclic carbenes, platelet-activating factor",

author = "Eleni Sioriki and Ronan Lordan and Fady Nahra and \{van Hecke\}, Kristof and Ioannis Zabetakis and Nolan, \{Steven P.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = dec,

day = "6",

doi = "10.1002/cmdc.201800601",

language = "English",

volume = "13",

pages = "2484--2487",

journal = "ChemMedChem",

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T1 - In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds

AU - Sioriki, Eleni

AU - Lordan, Ronan

AU - Nahra, Fady

AU - van Hecke, Kristof

AU - Zabetakis, Ioannis

AU - Nolan, Steven P.

PY - 2018/12/6

Y1 - 2018/12/6

N2 - The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.

AB - The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.

KW - anti-atherogenic activity

KW - atheromatosis

KW - aurates

KW - N-heterocyclic carbenes

KW - platelet-activating factor

UR - https://www.scopus.com/pages/publications/85057473574

U2 - 10.1002/cmdc.201800601

DO - 10.1002/cmdc.201800601

M3 - Article

C2 - 30381909

AN - SCOPUS:85057473574

SN - 1860-7179

VL - 13

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EP - 2487

JO - ChemMedChem

JF - ChemMedChem

IS - 23

ER -

In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds

Abstract

UN SDGs

Keywords

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