Inhibition of transcription by B cell leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50

Patricia E. Collins, Patrick A. Kiely, Ruaidhrí J. Carmody

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Bcl-3 is an essential negative regulator of cytokine expression. Results: A mutation in NF-κB p50 that prevents interaction with Bcl-3 abrogates Bcl-3 inhibition of gene expression. Conclusion: The inhibition of cytokine expression by Bcl-3 requires interaction with NF-κB p50. Significance: NF-κB p50 is the key target of Bcl-3 anti-inflammatory activity.

Original languageEnglish
Pages (from-to)7059-7067
Number of pages9
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
Publication statusPublished - 7 Mar 2014

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