TY - JOUR
T1 - Inhibition of transcription by B cell leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50
AU - Collins, Patricia E.
AU - Kiely, Patrick A.
AU - Carmody, Ruaidhrí J.
PY - 2014/3/7
Y1 - 2014/3/7
N2 - Background: Bcl-3 is an essential negative regulator of cytokine expression. Results: A mutation in NF-κB p50 that prevents interaction with Bcl-3 abrogates Bcl-3 inhibition of gene expression. Conclusion: The inhibition of cytokine expression by Bcl-3 requires interaction with NF-κB p50. Significance: NF-κB p50 is the key target of Bcl-3 anti-inflammatory activity.
AB - Background: Bcl-3 is an essential negative regulator of cytokine expression. Results: A mutation in NF-κB p50 that prevents interaction with Bcl-3 abrogates Bcl-3 inhibition of gene expression. Conclusion: The inhibition of cytokine expression by Bcl-3 requires interaction with NF-κB p50. Significance: NF-κB p50 is the key target of Bcl-3 anti-inflammatory activity.
UR - http://www.scopus.com/inward/record.url?scp=84896796684&partnerID=8YFLogxK
U2 - 10.1074/jbc.M114.551986
DO - 10.1074/jbc.M114.551986
M3 - Article
C2 - 24459141
AN - SCOPUS:84896796684
SN - 0021-9258
VL - 289
SP - 7059
EP - 7067
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 10
ER -