Inhibition of transcription by B cell leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50

Patricia E. Collins; Patrick A. Kiely; Ruaidhrí J. Carmody

doi:10.1074/jbc.M114.551986

Inhibition of transcription by B cell leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50

Patricia E. Collins
, Patrick A. Kiely
, Ruaidhrí J. Carmody

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Bcl-3 is an essential negative regulator of cytokine expression. Results: A mutation in NF-κB p50 that prevents interaction with Bcl-3 abrogates Bcl-3 inhibition of gene expression. Conclusion: The inhibition of cytokine expression by Bcl-3 requires interaction with NF-κB p50. Significance: NF-κB p50 is the key target of Bcl-3 anti-inflammatory activity.

Original language	English
Pages (from-to)	7059-7067
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	289
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M114.551986
Publication status	Published - 7 Mar 2014

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10.1074/jbc.M114.551986

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title = "Inhibition of transcription by B cell leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50",

abstract = "Background: Bcl-3 is an essential negative regulator of cytokine expression. Results: A mutation in NF-κB p50 that prevents interaction with Bcl-3 abrogates Bcl-3 inhibition of gene expression. Conclusion: The inhibition of cytokine expression by Bcl-3 requires interaction with NF-κB p50. Significance: NF-κB p50 is the key target of Bcl-3 anti-inflammatory activity.",

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AU - Kiely, Patrick A.

AU - Carmody, Ruaidhrí J.

PY - 2014/3/7

Y1 - 2014/3/7

N2 - Background: Bcl-3 is an essential negative regulator of cytokine expression. Results: A mutation in NF-κB p50 that prevents interaction with Bcl-3 abrogates Bcl-3 inhibition of gene expression. Conclusion: The inhibition of cytokine expression by Bcl-3 requires interaction with NF-κB p50. Significance: NF-κB p50 is the key target of Bcl-3 anti-inflammatory activity.

AB - Background: Bcl-3 is an essential negative regulator of cytokine expression. Results: A mutation in NF-κB p50 that prevents interaction with Bcl-3 abrogates Bcl-3 inhibition of gene expression. Conclusion: The inhibition of cytokine expression by Bcl-3 requires interaction with NF-κB p50. Significance: NF-κB p50 is the key target of Bcl-3 anti-inflammatory activity.

UR - https://www.scopus.com/pages/publications/84896796684

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JF - Journal of Biological Chemistry

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Inhibition of transcription by B cell leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50

Abstract

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