TY - JOUR
T1 - Injectable bottlebrush triblock copolymer hydrogel crosslinked with ferric ions
AU - Nakagawa, Yoshiyuki
AU - Oki, Yuichiro
AU - Da, Xiao
AU - Singh Chandel, Arvind K.
AU - Ohta, Seiichi
AU - Ito, Taichi
N1 - Publisher Copyright:
© 2022
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Metal ionically crosslinkable hydrogels are useful in many fields; however, it is difficult to design and synthesize them rationally. In this study, we synthesized ABA bottlebrush triblock copolymers, whose A block is poly(acrylic acid) (PAA) and B block is poly(oligo (ethylene glycol) methyl ether acrylate) (POEGA), by atom transfer radical polymerization. The obtained bottlebrush triblock copolymers, PAA-POEGA-PAAs, showed low viscosity at relatively high polymer concentrations and behaved as a Newtonian fluid below 20 wt% in aqueous solutions. The solutions were gelled by mixing with ferric ions after exceeding the overlap concentration. The G’ of the hydrogels increased sharply at the region of semi-dilute solutions before reaching the entanglement concentration. Thanks to the water-retention and steric effect of the bottlebrush structure of POEGA blocks, precipitation of the copolymers did not occur, but in situ and rapid gelling was possible via chelation of ferric ions by PAA blocks.
AB - Metal ionically crosslinkable hydrogels are useful in many fields; however, it is difficult to design and synthesize them rationally. In this study, we synthesized ABA bottlebrush triblock copolymers, whose A block is poly(acrylic acid) (PAA) and B block is poly(oligo (ethylene glycol) methyl ether acrylate) (POEGA), by atom transfer radical polymerization. The obtained bottlebrush triblock copolymers, PAA-POEGA-PAAs, showed low viscosity at relatively high polymer concentrations and behaved as a Newtonian fluid below 20 wt% in aqueous solutions. The solutions were gelled by mixing with ferric ions after exceeding the overlap concentration. The G’ of the hydrogels increased sharply at the region of semi-dilute solutions before reaching the entanglement concentration. Thanks to the water-retention and steric effect of the bottlebrush structure of POEGA blocks, precipitation of the copolymers did not occur, but in situ and rapid gelling was possible via chelation of ferric ions by PAA blocks.
KW - Bottlebrush polymers
KW - Hydrogels
KW - In situ gelation
KW - Ionic crosslinking
KW - Triblock copolymers
UR - https://www.scopus.com/pages/publications/85122323539
U2 - 10.1016/j.polymer.2022.124519
DO - 10.1016/j.polymer.2022.124519
M3 - Article
AN - SCOPUS:85122323539
SN - 0032-3861
VL - 240
JO - Polymer
JF - Polymer
M1 - 124519
ER -