Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish

Kathrin Reichwald; Andreas Petzold; Philipp Koch; Bryan R. Downie; Nils Hartmann; Stefan Pietsch; Mario Baumgart; Domitille Chalopin; Marius Felder; Martin Bens; Arne Sahm; Karol Szafranski; Stefan Taudien; Marco Groth; Ivan Arisi; Anja Weise; Samarth S. Bhatt; Virag Sharma; Johann M. Kraus; Florian Schmid; Steffen Priebe; Thomas Liehr; Matthias Görlach; Manuel E. Than; Michael Hiller; Hans A. Kestler; Jean Nicolas Volff; Manfred Schartl; Alessandro Cellerino; Christoph Englert; Matthias Platzer

doi:10.1016/j.cell.2015.10.071

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish

Kathrin Reichwald, Andreas Petzold, Philipp Koch, Bryan R. Downie, Nils Hartmann, Stefan Pietsch, Mario Baumgart, Domitille Chalopin, Marius Felder, Martin Bens, Arne Sahm, Karol Szafranski, Stefan Taudien, Marco Groth, Ivan Arisi, Anja Weise, Samarth S. Bhatt, Virag Sharma, Johann M. Kraus, Florian SchmidSteffen Priebe, Thomas Liehr, Matthias Görlach, Manuel E. Than, Michael Hiller, Hans A. Kestler, Jean Nicolas Volff, Manfred Schartl, Alessandro Cellerino, Christoph Englert, Matthias Platzer

Research output: Contribution to journal › Article › peer-review

Abstract

Summary The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing - in real time - different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).

Original language	English
Pages (from-to)	1527-1538
Number of pages	12
Journal	Cell
Volume	163
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2015.10.071
Publication status	Published - 3 Dec 2015
Externally published	Yes

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Reichwald, K., Petzold, A., Koch, P., Downie, B. R., Hartmann, N., Pietsch, S., Baumgart, M., Chalopin, D., Felder, M., Bens, M., Sahm, A., Szafranski, K., Taudien, S., Groth, M., Arisi, I., Weise, A., Bhatt, S. S., Sharma, V., Kraus, J. M., ... Platzer, M. (2015). Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish. Cell, 163(6), 1527-1538. https://doi.org/10.1016/j.cell.2015.10.071

@article{c79eb81b4a4f43ae8c02994d043dec14,

title = "Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish",

abstract = "Summary The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing - in real time - different stages of sex chromosome formation that display features of early mammalian XY evolution {"}in action.{"} Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).",

author = "Kathrin Reichwald and Andreas Petzold and Philipp Koch and Downie, {Bryan R.} and Nils Hartmann and Stefan Pietsch and Mario Baumgart and Domitille Chalopin and Marius Felder and Martin Bens and Arne Sahm and Karol Szafranski and Stefan Taudien and Marco Groth and Ivan Arisi and Anja Weise and Bhatt, {Samarth S.} and Virag Sharma and Kraus, {Johann M.} and Florian Schmid and Steffen Priebe and Thomas Liehr and Matthias G{\"o}rlach and Than, {Manuel E.} and Michael Hiller and Kestler, {Hans A.} and Volff, {Jean Nicolas} and Manfred Schartl and Alessandro Cellerino and Christoph Englert and Matthias Platzer",

year = "2015",

month = dec,

day = "3",

doi = "10.1016/j.cell.2015.10.071",

language = "English",

volume = "163",

pages = "1527--1538",

journal = "Cell",

issn = "0092-8674",

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Reichwald, K, Petzold, A, Koch, P, Downie, BR, Hartmann, N, Pietsch, S, Baumgart, M, Chalopin, D, Felder, M, Bens, M, Sahm, A, Szafranski, K, Taudien, S, Groth, M, Arisi, I, Weise, A, Bhatt, SS, Sharma, V, Kraus, JM, Schmid, F, Priebe, S, Liehr, T, Görlach, M, Than, ME, Hiller, M, Kestler, HA, Volff, JN, Schartl, M, Cellerino, A, Englert, C & Platzer, M 2015, 'Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish', Cell, vol. 163, no. 6, pp. 1527-1538. https://doi.org/10.1016/j.cell.2015.10.071

TY - JOUR

T1 - Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish

AU - Reichwald, Kathrin

AU - Petzold, Andreas

AU - Koch, Philipp

AU - Downie, Bryan R.

AU - Hartmann, Nils

AU - Pietsch, Stefan

AU - Baumgart, Mario

AU - Chalopin, Domitille

AU - Felder, Marius

AU - Bens, Martin

AU - Sahm, Arne

AU - Szafranski, Karol

AU - Taudien, Stefan

AU - Groth, Marco

AU - Arisi, Ivan

AU - Weise, Anja

AU - Bhatt, Samarth S.

AU - Sharma, Virag

AU - Kraus, Johann M.

AU - Schmid, Florian

AU - Priebe, Steffen

AU - Liehr, Thomas

AU - Görlach, Matthias

AU - Than, Manuel E.

AU - Hiller, Michael

AU - Kestler, Hans A.

AU - Volff, Jean Nicolas

AU - Schartl, Manfred

AU - Cellerino, Alessandro

AU - Englert, Christoph

AU - Platzer, Matthias

PY - 2015/12/3

Y1 - 2015/12/3

N2 - Summary The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing - in real time - different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).

AB - Summary The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing - in real time - different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).

UR - http://www.scopus.com/inward/record.url?scp=84949209188&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2015.10.071

DO - 10.1016/j.cell.2015.10.071

M3 - Article

C2 - 26638077

AN - SCOPUS:84949209188

SN - 0092-8674

VL - 163

SP - 1527

EP - 1538

JO - Cell

JF - Cell

IS - 6

ER -

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish

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