TY - JOUR
T1 - Insights on the health benefits of the bioactive compounds of coffee silverskin extract
AU - Fernandez-Gomez, Beatriz
AU - Lezama, Adriana
AU - Amigo-Benavent, Miryam
AU - Ullate, Mónica
AU - Herrero, Miguel
AU - Martín, María Ángeles
AU - Mesa, Maria Dolores
AU - del Castillo, Maria Dolores
N1 - Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.
AB - The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.
KW - Bioaccessibility
KW - Caffeine
KW - Chlorogenic acid
KW - Coffee silverskin
KW - Metabolism
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84973872411&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2016.06.001
DO - 10.1016/j.jff.2016.06.001
M3 - Article
AN - SCOPUS:84973872411
SN - 1756-4646
VL - 25
SP - 197
EP - 207
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -
