Insights on the health benefits of the bioactive compounds of coffee silverskin extract

Beatriz Fernandez-Gomez; Adriana Lezama; Miryam Amigo-Benavent; Mónica Ullate; Miguel Herrero; María Ángeles Martín; Maria Dolores Mesa; Maria Dolores del Castillo

doi:10.1016/j.jff.2016.06.001

Insights on the health benefits of the bioactive compounds of coffee silverskin extract

Beatriz Fernandez-Gomez
, Adriana Lezama
, Miryam Amigo-Benavent
, Mónica Ullate
, Miguel Herrero
, María Ángeles Martín
, Maria Dolores Mesa
, Maria Dolores del Castillo

Institute of Food Science Research (CIAL CSIC-UAM)
Technology and Nutrition (ICTAN - CSIC)
Instituto de Salud Carlos III
University of Granada
Instituto de Investigación Biosanitaria (IBS)
Universidad Autónoma de Madrid

Research output: Contribution to journal › Article › peer-review

Abstract

The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.

Original language	English
Pages (from-to)	197-207
Number of pages	11
Journal	Journal of Functional Foods
Volume	25
DOIs	https://doi.org/10.1016/j.jff.2016.06.001
Publication status	Published - 1 Aug 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bioaccessibility
Caffeine
Chlorogenic acid
Coffee silverskin
Metabolism
Type 2 diabetes

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10.1016/j.jff.2016.06.001

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title = "Insights on the health benefits of the bioactive compounds of coffee silverskin extract",

abstract = "The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.",

keywords = "Bioaccessibility, Caffeine, Chlorogenic acid, Coffee silverskin, Metabolism, Type 2 diabetes",

author = "Beatriz Fernandez-Gomez and Adriana Lezama and Miryam Amigo-Benavent and M{\'o}nica Ullate and Miguel Herrero and Mart{\'i}n, \{Mar{\'i}a {\'A}ngeles\} and Mesa, \{Maria Dolores\} and \{del Castillo\}, \{Maria Dolores\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

month = aug,

day = "1",

doi = "10.1016/j.jff.2016.06.001",

language = "English",

volume = "25",

pages = "197--207",

journal = "Journal of Functional Foods",

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T1 - Insights on the health benefits of the bioactive compounds of coffee silverskin extract

AU - Fernandez-Gomez, Beatriz

AU - Lezama, Adriana

AU - Amigo-Benavent, Miryam

AU - Ullate, Mónica

AU - Herrero, Miguel

AU - Martín, María Ángeles

AU - Mesa, Maria Dolores

AU - del Castillo, Maria Dolores

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.

AB - The bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.

KW - Bioaccessibility

KW - Caffeine

KW - Chlorogenic acid

KW - Coffee silverskin

KW - Metabolism

KW - Type 2 diabetes

UR - https://www.scopus.com/pages/publications/84973872411

U2 - 10.1016/j.jff.2016.06.001

DO - 10.1016/j.jff.2016.06.001

M3 - Article

AN - SCOPUS:84973872411

SN - 1756-4646

VL - 25

SP - 197

EP - 207

JO - Journal of Functional Foods

JF - Journal of Functional Foods

ER -

Insights on the health benefits of the bioactive compounds of coffee silverskin extract

Abstract

UN SDGs

Keywords

Access to Document

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