Interferon-γ-induced priming for secretion of Superoxide anion and tumor necrosis factor-α declines in macrophages from aged rats

Donna R. Davila; Carl K. Edwards; Sean Arkins; Joseph Simon; Keith W. Kelley

Interferon-γ-induced priming for secretion of Superoxide anion and tumor necrosis factor-α declines in macrophages from aged rats

Donna R. Davila, Carl K. Edwards, Sean Arkins, Joseph Simon, Keith W. Kelley

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophage responses to recombinant IFN-γ decline during aging, as measured by two criteria of macrophage activation, O₂^- and TNF-α secretion. The production of O₂^- by macrophages in response to opsonized-zymosan and recombinant rat IFN-γ is 75% lower in 23-month-old rats than in 3-monthold rats. Furthermore, the secretion of TNF-α in response to IFN-γ and LPS is almost absent in macrophages from aged rats. Production of both O₂^- and TNF-α by resident peritoneal macrophages from specific pathogen-free aged rats in response to priming and triggering stimuli was partially or fully restored by implantation of syngeneic pituitary grafts from young rats. These data demonstrate that macrophages from aged rats are defective in their response to a priming signal induced by IFN-γ, and they suggest that impaired macrophage responses during aging may be reversible.

Original language	English
Pages (from-to)	2906-2911
Number of pages	6
Journal	FASEB Journal
Volume	4
Issue number	11
Publication status	Published - 1990
Externally published	Yes

Keywords

Aging
Macrophage activation
Superoxide anion
Tumor necrosis factor-α

Cite this

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title = "Interferon-γ-induced priming for secretion of Superoxide anion and tumor necrosis factor-α declines in macrophages from aged rats",

abstract = "Macrophage responses to recombinant IFN-γ decline during aging, as measured by two criteria of macrophage activation, O2- and TNF-α secretion. The production of O2- by macrophages in response to opsonized-zymosan and recombinant rat IFN-γ is 75% lower in 23-month-old rats than in 3-monthold rats. Furthermore, the secretion of TNF-α in response to IFN-γ and LPS is almost absent in macrophages from aged rats. Production of both O2- and TNF-α by resident peritoneal macrophages from specific pathogen-free aged rats in response to priming and triggering stimuli was partially or fully restored by implantation of syngeneic pituitary grafts from young rats. These data demonstrate that macrophages from aged rats are defective in their response to a priming signal induced by IFN-γ, and they suggest that impaired macrophage responses during aging may be reversible.",

keywords = "Aging, Macrophage activation, Superoxide anion, Tumor necrosis factor-α",

author = "Davila, {Donna R.} and Edwards, {Carl K.} and Sean Arkins and Joseph Simon and Kelley, {Keith W.}",

year = "1990",

language = "English",

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TY - JOUR

T1 - Interferon-γ-induced priming for secretion of Superoxide anion and tumor necrosis factor-α declines in macrophages from aged rats

AU - Davila, Donna R.

AU - Edwards, Carl K.

AU - Arkins, Sean

AU - Simon, Joseph

AU - Kelley, Keith W.

PY - 1990

Y1 - 1990

N2 - Macrophage responses to recombinant IFN-γ decline during aging, as measured by two criteria of macrophage activation, O2- and TNF-α secretion. The production of O2- by macrophages in response to opsonized-zymosan and recombinant rat IFN-γ is 75% lower in 23-month-old rats than in 3-monthold rats. Furthermore, the secretion of TNF-α in response to IFN-γ and LPS is almost absent in macrophages from aged rats. Production of both O2- and TNF-α by resident peritoneal macrophages from specific pathogen-free aged rats in response to priming and triggering stimuli was partially or fully restored by implantation of syngeneic pituitary grafts from young rats. These data demonstrate that macrophages from aged rats are defective in their response to a priming signal induced by IFN-γ, and they suggest that impaired macrophage responses during aging may be reversible.

AB - Macrophage responses to recombinant IFN-γ decline during aging, as measured by two criteria of macrophage activation, O2- and TNF-α secretion. The production of O2- by macrophages in response to opsonized-zymosan and recombinant rat IFN-γ is 75% lower in 23-month-old rats than in 3-monthold rats. Furthermore, the secretion of TNF-α in response to IFN-γ and LPS is almost absent in macrophages from aged rats. Production of both O2- and TNF-α by resident peritoneal macrophages from specific pathogen-free aged rats in response to priming and triggering stimuli was partially or fully restored by implantation of syngeneic pituitary grafts from young rats. These data demonstrate that macrophages from aged rats are defective in their response to a priming signal induced by IFN-γ, and they suggest that impaired macrophage responses during aging may be reversible.

KW - Aging

KW - Macrophage activation

KW - Superoxide anion

KW - Tumor necrosis factor-α

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M3 - Article

C2 - 2165948

AN - SCOPUS:0025244176

SN - 0892-6638

VL - 4

SP - 2906

EP - 2911

JO - FASEB Journal

JF - FASEB Journal

IS - 11

ER -

Interferon-γ-induced priming for secretion of Superoxide anion and tumor necrosis factor-α declines in macrophages from aged rats

Abstract

Keywords

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