TY - CHAP
T1 - Intracoronary application of TiO2-coated cardiovascular stents
AU - Wawrzynska, Magdalena
AU - Kopaczynska, Marta
AU - Sobieszczanska, Beata
AU - Ulatowska-Jarza, Agnieszka
AU - Holowacz, Iwona
AU - Bialy, Dariusz
AU - Paslawska, Urszula
AU - Wasyluk, Lukasz
AU - Tofail, Syed A.M.
AU - Bauer, Joanna
AU - Podbielska, Halina
N1 - Publisher Copyright:
© 2016 by Imperial College Press.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Intravascular stenting of atherosclerotic coronary arteries is a life-saving, widely-used procedure in interventional cardiology. Adverse clinical outcomes such as restenosis highlight the importance of meeting the excellent biocompatibility by cardiovascular implants. In this chapter, a newly developed photoactive titania-based nanomaterial has been described for cardiovascular stent coating. The biocompatibility of these nanotitania based-coatings has been compared with that of 316L stainless steel surfaces typically used in commercial coronary stents. Titania-based stent coatings were tested in vivo for the safety of use and compatibility with the artery wall tissues and blood components. Titania-coated stents have shown the non-inferiority status with respect to bare metal 316 L stainless steel control stents. In vitro data showed relatively less fibrinogen on titania coatings indicating better haemocompatibility and lower thrombogenecity in comparison to 316 L. Titania coatings generally possess higher surface potential (SP) and better bio- and haemocompatibility and make such coatings promising candidates in cardiovascular graft applications.
AB - Intravascular stenting of atherosclerotic coronary arteries is a life-saving, widely-used procedure in interventional cardiology. Adverse clinical outcomes such as restenosis highlight the importance of meeting the excellent biocompatibility by cardiovascular implants. In this chapter, a newly developed photoactive titania-based nanomaterial has been described for cardiovascular stent coating. The biocompatibility of these nanotitania based-coatings has been compared with that of 316L stainless steel surfaces typically used in commercial coronary stents. Titania-based stent coatings were tested in vivo for the safety of use and compatibility with the artery wall tissues and blood components. Titania-coated stents have shown the non-inferiority status with respect to bare metal 316 L stainless steel control stents. In vitro data showed relatively less fibrinogen on titania coatings indicating better haemocompatibility and lower thrombogenecity in comparison to 316 L. Titania coatings generally possess higher surface potential (SP) and better bio- and haemocompatibility and make such coatings promising candidates in cardiovascular graft applications.
UR - http://www.scopus.com/inward/record.url?scp=85019854114&partnerID=8YFLogxK
U2 - 10.1142/9781783269877_0020
DO - 10.1142/9781783269877_0020
M3 - Chapter
AN - SCOPUS:85019854114
SN - 9781783269860
SP - 279
EP - 296
BT - Electrically Active Materials for Medical Devices
PB - Imperial College Press
ER -