Investigating the influence of Na+ and Sr2+ on the structure and solubility of SiO2–TiO2–CaO–Na2O/SrO bioactive glass

Y. Li; L. M. Placek; A. Coughlan; F. R. Laffir; D. Pradhan; N. P. Mellott; A. W. Wren

doi:10.1007/s10856-015-5415-5

Investigating the influence of Na⁺ and Sr²⁺ on the structure and solubility of SiO₂–TiO₂–CaO–Na₂O/SrO bioactive glass

Y. Li, L. M. Placek, A. Coughlan, F. R. Laffir, D. Pradhan, N. P. Mellott, A. W. Wren

Research output: Contribution to journal › Article › peer-review

Abstract

This study was conducted to determine the influence that network modifiers, sodium (Na⁺) and strontium (Sr²⁺), have on the solubility of a SiO₂–TiO₂–CaO–Na₂O/SrO bioactive glass. Glass characterization determined each composition had a similar structure, i.e. bridging to non-bridging oxygen ratio determined by X-ray photoelectron spectroscopy. Magic angle spinning nuclear magnetic resonance (MAS-NMR) confirmed structural similarities as each glass presented spectral shifts between −84 and −85 ppm. Differential thermal analysis and hardness testing revealed higher glass transition temperatures (T_g 591–760 °C) and hardness values (2.4–6.1 GPa) for the Sr²⁺ containing glasses. Additionally the Sr²⁺ (~250 mg/L) containing glasses displayed much lower ion release rates than the Na⁺ (~1,200 mg/L) containing glass analogues. With the reduction in ion release there was an associated reduction in solution pH. Cytotoxicity and cell adhesion studies were conducted using MC3T3 Osteoblasts. Each glass did not significantly reduce cell numbers and osteoblasts were found to adhere to each glass surface.

Original language	English
Pages (from-to)	85
Journal	Journal of Materials Science: Materials in Medicine
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/s10856-015-5415-5
Publication status	Published - Feb 2015

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title = "Investigating the influence of Na+ and Sr2+ on the structure and solubility of SiO2–TiO2–CaO–Na2O/SrO bioactive glass",

abstract = "This study was conducted to determine the influence that network modifiers, sodium (Na+) and strontium (Sr2+), have on the solubility of a SiO2–TiO2–CaO–Na2O/SrO bioactive glass. Glass characterization determined each composition had a similar structure, i.e. bridging to non-bridging oxygen ratio determined by X-ray photoelectron spectroscopy. Magic angle spinning nuclear magnetic resonance (MAS-NMR) confirmed structural similarities as each glass presented spectral shifts between −84 and −85 ppm. Differential thermal analysis and hardness testing revealed higher glass transition temperatures (Tg 591–760 °C) and hardness values (2.4–6.1 GPa) for the Sr2+ containing glasses. Additionally the Sr2+ (~250 mg/L) containing glasses displayed much lower ion release rates than the Na+ (~1,200 mg/L) containing glass analogues. With the reduction in ion release there was an associated reduction in solution pH. Cytotoxicity and cell adhesion studies were conducted using MC3T3 Osteoblasts. Each glass did not significantly reduce cell numbers and osteoblasts were found to adhere to each glass surface.",

author = "Y. Li and Placek, {L. M.} and A. Coughlan and Laffir, {F. R.} and D. Pradhan and Mellott, {N. P.} and Wren, {A. W.}",

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AU - Li, Y.

AU - Placek, L. M.

AU - Coughlan, A.

AU - Laffir, F. R.

AU - Pradhan, D.

AU - Mellott, N. P.

AU - Wren, A. W.

PY - 2015/2

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Investigating the influence of Na⁺ and Sr²⁺ on the structure and solubility of SiO₂–TiO₂–CaO–Na₂O/SrO bioactive glass

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