TY - JOUR
T1 - Is a higher ingestion of phenolic compounds the best dietary strategy? A scientific opinion on the deleterious effects of polyphenols in vivo
AU - Granato, Daniel
AU - Mocan, Andrei
AU - Câmara, José S.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/4
Y1 - 2020/4
N2 - Background: Phenolic compounds have been studied for a variety number of bioactivities using in vitro, ex vivo, and in vivo protocols. Most of the studies dealing with phenolic compounds deal with in vitro antioxidant, antihypertensive, anti-inflammatory, antipyretic, antihemolytic effects in human erythrocytes, hypolipidemic, and antiproliferative activities. Scope and approach: Companies have used the overall understanding of the beneficial effects of polyphenols to develop “functional” foods and ingredients. However, the main question that arises is still the target of warm discussions: Is the higher ingestion of phenolic compounds the best dietary strategy? Our commentary focuses on this question and we list some examples in which phenolic compounds show deleterious effects in vivo. Key findings and conclusions: Two main conclusions arise: (i) any presumption of “functional effects” based on test-tube studies should be avoided as these results do not represent the real biological effect in humans; (ii) at high concentrations and in specific populations, polyphenols may have several potential adverse health effects presumably associated to their pro-oxidative capacity. All in one, the dietary supplementation containing high doses of polyphenols should be well justified in each case until a consensus is reached supported on medical, nutritional and toxicological data.
AB - Background: Phenolic compounds have been studied for a variety number of bioactivities using in vitro, ex vivo, and in vivo protocols. Most of the studies dealing with phenolic compounds deal with in vitro antioxidant, antihypertensive, anti-inflammatory, antipyretic, antihemolytic effects in human erythrocytes, hypolipidemic, and antiproliferative activities. Scope and approach: Companies have used the overall understanding of the beneficial effects of polyphenols to develop “functional” foods and ingredients. However, the main question that arises is still the target of warm discussions: Is the higher ingestion of phenolic compounds the best dietary strategy? Our commentary focuses on this question and we list some examples in which phenolic compounds show deleterious effects in vivo. Key findings and conclusions: Two main conclusions arise: (i) any presumption of “functional effects” based on test-tube studies should be avoided as these results do not represent the real biological effect in humans; (ii) at high concentrations and in specific populations, polyphenols may have several potential adverse health effects presumably associated to their pro-oxidative capacity. All in one, the dietary supplementation containing high doses of polyphenols should be well justified in each case until a consensus is reached supported on medical, nutritional and toxicological data.
KW - Antioxidant dietary supplements
KW - Polyphenols
KW - Pro-oxidative effects
KW - Reactive oxygen species
KW - Toxic effects
UR - http://www.scopus.com/inward/record.url?scp=85078205745&partnerID=8YFLogxK
U2 - 10.1016/j.tifs.2020.01.010
DO - 10.1016/j.tifs.2020.01.010
M3 - Comment/debate
AN - SCOPUS:85078205745
SN - 0924-2244
VL - 98
SP - 162
EP - 166
JO - Trends in Food Science and Technology
JF - Trends in Food Science and Technology
ER -