Ischaemia‐reperfusion injury

Research output: Contribution to journalReview articlepeer-review

Abstract

Ischaemia‐reperfusion injury is a complex phenomenon often encountered in surgical practice. The consequences of such injury are local and remote tissue destruction, and sometimes death. Several different processes have been implicated. This review discusses the pathology of such injury, the mechanisms of free radical production, and the role of neutrophils and endothelial factors in ischaemiareperfusion. Finally, several mechanisms that limit ischaemiareperfusion injury are discussed and a number of novel therapies presented.

Original languageEnglish
Pages (from-to)637-647
Number of pages11
JournalBritish Journal of Surgery
Volume81
Issue number5
DOIs
Publication statusPublished - May 1994
Externally publishedYes

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