TY - JOUR
T1 - Knitting the Threads of Silk through Time
T2 - Behçet's Disease - Past, Present, and Future
AU - Adeeb, Fahd
AU - Stack, Austin G.
AU - Fraser, Alexander D.
N1 - Publisher Copyright:
© 2017 Fahd Adeeb et al.
PY - 2017
Y1 - 2017
N2 - Behçet's disease (BD) is a chronic relapsing vasculitis that affects vessels of all types and sizes with a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. Efforts by the scientific community to resolve the unmet needs of BD and gaps in our knowledge have been hampered by considerable challenges that primarily relate to the rare nature of the disease in many parts of the world and its heterogeneity. Controversies remain in many aspects of the disease including the diagnostic criteria, immunopathogenesis and biomarker discovery, geographical variation, and therapeutic considerations. In this review, we highlight recent advances in our scientific understanding of BD, shed new insights into diagnostic and treatment strategies, and discuss residual gaps in our knowledge that will serve as the basis for current and future research.
AB - Behçet's disease (BD) is a chronic relapsing vasculitis that affects vessels of all types and sizes with a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. Efforts by the scientific community to resolve the unmet needs of BD and gaps in our knowledge have been hampered by considerable challenges that primarily relate to the rare nature of the disease in many parts of the world and its heterogeneity. Controversies remain in many aspects of the disease including the diagnostic criteria, immunopathogenesis and biomarker discovery, geographical variation, and therapeutic considerations. In this review, we highlight recent advances in our scientific understanding of BD, shed new insights into diagnostic and treatment strategies, and discuss residual gaps in our knowledge that will serve as the basis for current and future research.
UR - http://www.scopus.com/inward/record.url?scp=85030635301&partnerID=8YFLogxK
U2 - 10.1155/2017/2160610
DO - 10.1155/2017/2160610
M3 - Review article
AN - SCOPUS:85030635301
SN - 1687-9260
VL - 2017
JO - International Journal of Rheumatology
JF - International Journal of Rheumatology
M1 - 2160610
ER -