TY - JOUR
T1 - Magnetic hydrogel (MagGel)
T2 - An evolutionary pedestal for anticancer therapy
AU - Londhe, Prajkta V.
AU - Londhe, Maithili V.
AU - Salunkhe, Ashwini B.
AU - Laha, Suvra S.
AU - Mefford, O. Thompson
AU - Thorat, Nanasaheb D.
AU - Khot, Vishwajeet M.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Recent advancement in biomaterials have led to the development of magnetic hydrogel as promising tool for anticancer therapy. Magnetic hydrogels improve injectability over bare nanoparticles by controlling particle dispersion and reducing aggregation, ensuring uniform delivery and minimizing clogging, thereby enhancing anticancer therapy effectiveness and safety. This review explores the fundamental crosslinking methodologies and chemical strategies for the formation of hydrogels, transitioning into detailed discussions on the synthesis of magnetic hydrogels, emphasizing their unique properties essential for biomedical applications. Key properties such as injectability, shear thinning, biocompatibility, porosity, mechanical properties, and biodegradability underpinning the efficacy of magnetic hydrogels in biomedical applications are discussed. Furthermore, the review highlights the diverse applications of magnetic hydrogels in the biomedical field, including hyperthermia, MRI-guided therapy, targeted drug delivery, and tissue engineering. These properties and applications demonstrate the potential of magnetic hydrogels to revolutionize cancer treatment and other medical therapies, offering a multifunctional platform that can address various biomedical challenges with enhanced precision and effectiveness. Finally, future research trends and applications of magnetic hydrogels are also recommended and examined.
AB - Recent advancement in biomaterials have led to the development of magnetic hydrogel as promising tool for anticancer therapy. Magnetic hydrogels improve injectability over bare nanoparticles by controlling particle dispersion and reducing aggregation, ensuring uniform delivery and minimizing clogging, thereby enhancing anticancer therapy effectiveness and safety. This review explores the fundamental crosslinking methodologies and chemical strategies for the formation of hydrogels, transitioning into detailed discussions on the synthesis of magnetic hydrogels, emphasizing their unique properties essential for biomedical applications. Key properties such as injectability, shear thinning, biocompatibility, porosity, mechanical properties, and biodegradability underpinning the efficacy of magnetic hydrogels in biomedical applications are discussed. Furthermore, the review highlights the diverse applications of magnetic hydrogels in the biomedical field, including hyperthermia, MRI-guided therapy, targeted drug delivery, and tissue engineering. These properties and applications demonstrate the potential of magnetic hydrogels to revolutionize cancer treatment and other medical therapies, offering a multifunctional platform that can address various biomedical challenges with enhanced precision and effectiveness. Finally, future research trends and applications of magnetic hydrogels are also recommended and examined.
KW - Anticancer therapy
KW - Biocompatibility
KW - Hyperthermia
KW - Magnetic hydrogel
KW - Magnetic nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85204427954&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2024.216228
DO - 10.1016/j.ccr.2024.216228
M3 - Review article
AN - SCOPUS:85204427954
SN - 0010-8545
VL - 522
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 216228
ER -
