Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy

J. Van Erps; Agnieszka Gierej; Tigran Baghdasaryan; Michael Martyn; Peter Woulfe; Owen Mc Laughlin; Kevin Prise; Geraldine Workman; Sinead O'Keeffe; Kurt Rochlitz; Sergey Verlinski; Agnese Giaz; Romualdo Santoro; Massimo Caccia; Francis Berghmans

doi:10.1117/12.3043631

Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy

J. Van Erps
, Agnieszka Gierej
, Tigran Baghdasaryan
, Michael Martyn
, Peter Woulfe
, Owen Mc Laughlin
, Kevin Prise
, Geraldine Workman
, Sinead O'Keeffe
, Kurt Rochlitz
, Sergey Verlinski
, Agnese Giaz
, Romualdo Santoro
, Massimo Caccia
, Francis Berghmans

Department of Electronics & Computer Engineering

Vrije Universiteit Brussel
Galway Clinic
University of Galway
Queen's University Belfast
University of Insubria

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Scintillation-based fiber dosimeters are a powerful tool for minimally invasive localized real-time monitoring of the dose rate during brachytherapy (BT). We present a fabrication method for mass manufacturing of scintillating sensor tips which are to be attached to polymer optical fiber (POF) to enable fiber-optic dosimetry. The scintillating sensor tips consist of inorganic scintillators, dispersed in a polymer host. The manufacturing is done by means of a custom compression and transfer moulding process implemented on a commercially available hot embossing machine. We show the manufacturing of 237 sensor tips, which are subsequently attached to the end of the POF using UV-curable adhesive. Finally, we perform dosimetry experiments in water phantoms which show a great potential for in-vivo dosimetry for brachytherapy, both for Low Dose Rate (LDR) and High Dose Rate (HDR) BT.

Original language	English
Title of host publication	Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV
Editors	Israel Gannot, Israel Gannot, Katy Roodenko
Publisher	SPIE
ISBN (Electronic)	9781510683686
DOIs	https://doi.org/10.1117/12.3043631
Publication status	Published - 2025
Event	Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV 2025 - San Francisco, United States Duration: 25 Jan 2025 → 28 Jan 2025

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	13310
ISSN (Print)	1605-7422

Conference

Conference	Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV 2025
Country/Territory	United States
City	San Francisco
Period	25/01/25 → 28/01/25

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

Brachytherapy
Compression Moulding
Inorganic Scintillators
Optical Fiber Sensors
Plastic Optical Fiber
Radiation Sensor
Transfer Moulding

Access to Document

10.1117/12.3043631

Cite this

Van Erps, J., Gierej, A., Baghdasaryan, T., Martyn, M., Woulfe, P., Mc Laughlin, O., Prise, K., Workman, G., O'Keeffe, S., Rochlitz, K., Verlinski, S., Giaz, A., Santoro, R., Caccia, M., & Berghmans, F. (2025). Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy. In I. Gannot, I. Gannot, & K. Roodenko (Eds.), Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV Article 133100I (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13310). SPIE. https://doi.org/10.1117/12.3043631

Van Erps, J. ; Gierej, Agnieszka ; Baghdasaryan, Tigran et al. / Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy. Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV. editor / Israel Gannot ; Israel Gannot ; Katy Roodenko. SPIE, 2025. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{837b7a8cdd0d4653a835b57fc359710c,

title = "Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy",

abstract = "Scintillation-based fiber dosimeters are a powerful tool for minimally invasive localized real-time monitoring of the dose rate during brachytherapy (BT). We present a fabrication method for mass manufacturing of scintillating sensor tips which are to be attached to polymer optical fiber (POF) to enable fiber-optic dosimetry. The scintillating sensor tips consist of inorganic scintillators, dispersed in a polymer host. The manufacturing is done by means of a custom compression and transfer moulding process implemented on a commercially available hot embossing machine. We show the manufacturing of 237 sensor tips, which are subsequently attached to the end of the POF using UV-curable adhesive. Finally, we perform dosimetry experiments in water phantoms which show a great potential for in-vivo dosimetry for brachytherapy, both for Low Dose Rate (LDR) and High Dose Rate (HDR) BT.",

keywords = "Brachytherapy, Compression Moulding, Inorganic Scintillators, Optical Fiber Sensors, Plastic Optical Fiber, Radiation Sensor, Transfer Moulding",

author = "\{Van Erps\}, J. and Agnieszka Gierej and Tigran Baghdasaryan and Michael Martyn and Peter Woulfe and \{Mc Laughlin\}, Owen and Kevin Prise and Geraldine Workman and Sinead O'Keeffe and Kurt Rochlitz and Sergey Verlinski and Agnese Giaz and Romualdo Santoro and Massimo Caccia and Francis Berghmans",

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doi = "10.1117/12.3043631",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Israel Gannot and Israel Gannot and Katy Roodenko",

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}

Van Erps, J, Gierej, A, Baghdasaryan, T, Martyn, M, Woulfe, P, Mc Laughlin, O, Prise, K, Workman, G, O'Keeffe, S, Rochlitz, K, Verlinski, S, Giaz, A, Santoro, R, Caccia, M & Berghmans, F 2025, Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy. in I Gannot, I Gannot & K Roodenko (eds), Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV., 133100I, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13310, SPIE, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV 2025, San Francisco, United States, 25/01/25. https://doi.org/10.1117/12.3043631

Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy. / Van Erps, J.; Gierej, Agnieszka; Baghdasaryan, Tigran et al.
Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV. ed. / Israel Gannot; Israel Gannot; Katy Roodenko. SPIE, 2025. 133100I (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 13310).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy

AU - Van Erps, J.

AU - Gierej, Agnieszka

AU - Baghdasaryan, Tigran

AU - Martyn, Michael

AU - Woulfe, Peter

AU - Mc Laughlin, Owen

AU - Prise, Kevin

AU - Workman, Geraldine

AU - O'Keeffe, Sinead

AU - Rochlitz, Kurt

AU - Verlinski, Sergey

AU - Giaz, Agnese

AU - Santoro, Romualdo

AU - Caccia, Massimo

AU - Berghmans, Francis

PY - 2025

Y1 - 2025

N2 - Scintillation-based fiber dosimeters are a powerful tool for minimally invasive localized real-time monitoring of the dose rate during brachytherapy (BT). We present a fabrication method for mass manufacturing of scintillating sensor tips which are to be attached to polymer optical fiber (POF) to enable fiber-optic dosimetry. The scintillating sensor tips consist of inorganic scintillators, dispersed in a polymer host. The manufacturing is done by means of a custom compression and transfer moulding process implemented on a commercially available hot embossing machine. We show the manufacturing of 237 sensor tips, which are subsequently attached to the end of the POF using UV-curable adhesive. Finally, we perform dosimetry experiments in water phantoms which show a great potential for in-vivo dosimetry for brachytherapy, both for Low Dose Rate (LDR) and High Dose Rate (HDR) BT.

AB - Scintillation-based fiber dosimeters are a powerful tool for minimally invasive localized real-time monitoring of the dose rate during brachytherapy (BT). We present a fabrication method for mass manufacturing of scintillating sensor tips which are to be attached to polymer optical fiber (POF) to enable fiber-optic dosimetry. The scintillating sensor tips consist of inorganic scintillators, dispersed in a polymer host. The manufacturing is done by means of a custom compression and transfer moulding process implemented on a commercially available hot embossing machine. We show the manufacturing of 237 sensor tips, which are subsequently attached to the end of the POF using UV-curable adhesive. Finally, we perform dosimetry experiments in water phantoms which show a great potential for in-vivo dosimetry for brachytherapy, both for Low Dose Rate (LDR) and High Dose Rate (HDR) BT.

KW - Brachytherapy

KW - Compression Moulding

KW - Inorganic Scintillators

KW - Optical Fiber Sensors

KW - Plastic Optical Fiber

KW - Radiation Sensor

KW - Transfer Moulding

UR - https://www.scopus.com/pages/publications/105004220226

U2 - 10.1117/12.3043631

DO - 10.1117/12.3043631

M3 - Conference contribution

AN - SCOPUS:105004220226

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV

A2 - Gannot, Israel

A2 - Roodenko, Katy

PB - SPIE

T2 - Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV 2025

Y2 - 25 January 2025 through 28 January 2025

ER -

Van Erps J, Gierej A, Baghdasaryan T, Martyn M, Woulfe P, Mc Laughlin O et al. Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy. In Gannot I, Gannot I, Roodenko K, editors, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXV. SPIE. 2025. 133100I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.3043631

Mass Manufacturable Scintillation-based Optical Fiber Dosimeters for Brachytherapy

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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