TY - JOUR
T1 - Mechanical behaviour of nitric oxide releasing polymers for cardiovascular bypass grafts
AU - Tabish, Tanveer A.
AU - Thorat, Nanasaheb D.
AU - Narayan, Roger J.
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2023/1
Y1 - 2023/1
N2 - The advents of balloon angioplasty and of vascular bypass grafts have resulted in a paradigm shift in the management of cardiovascular diseases, but thrombus formation rising from the progression of intimal hyperplasia due to vessel damage and delayed arterial healing continue to be an intractable clinical failure of synthetic vascular bypass grafts. Nitric oxide (NO) releasing vascular bypass grafts have been developed as alternatives to conventional vascular grafts, but concerns over their short patency owing to the dissimilarity of mechanical properties between bypass grafts and innate arteries have recently been raised. Mismatch in mechanical properties at the endways inosculation of an artery and graft causes shear rate instabilities, which in turn stimulates intimal hyperplasia, thereby leading to graft failure. With the rapid development of manufacturing of innovative bypass grafts, no intervention has hitherto unequivocally proven to be clinically viscoelastic in preventing bypass graft failure. An ideal vascular graft closely mimics the structure and mechanical functions of native blood vessels and the configuration of each layer of the blood vessel. The overarching goal of this perspective is to highlight the importance and effects of mechanical properties of NO-releasing grafts in achieving optimal therapeutic outcomes for the management of cardiovascular diseases.
AB - The advents of balloon angioplasty and of vascular bypass grafts have resulted in a paradigm shift in the management of cardiovascular diseases, but thrombus formation rising from the progression of intimal hyperplasia due to vessel damage and delayed arterial healing continue to be an intractable clinical failure of synthetic vascular bypass grafts. Nitric oxide (NO) releasing vascular bypass grafts have been developed as alternatives to conventional vascular grafts, but concerns over their short patency owing to the dissimilarity of mechanical properties between bypass grafts and innate arteries have recently been raised. Mismatch in mechanical properties at the endways inosculation of an artery and graft causes shear rate instabilities, which in turn stimulates intimal hyperplasia, thereby leading to graft failure. With the rapid development of manufacturing of innovative bypass grafts, no intervention has hitherto unequivocally proven to be clinically viscoelastic in preventing bypass graft failure. An ideal vascular graft closely mimics the structure and mechanical functions of native blood vessels and the configuration of each layer of the blood vessel. The overarching goal of this perspective is to highlight the importance and effects of mechanical properties of NO-releasing grafts in achieving optimal therapeutic outcomes for the management of cardiovascular diseases.
KW - Biomechanics
KW - Mechanical properties
KW - Nitric oxide
KW - Polymers
KW - Vascular bypass grafts
UR - http://www.scopus.com/inward/record.url?scp=85142205132&partnerID=8YFLogxK
U2 - 10.1016/j.mechmat.2022.104520
DO - 10.1016/j.mechmat.2022.104520
M3 - Article
AN - SCOPUS:85142205132
SN - 0167-6636
VL - 176
JO - Mechanics of Materials
JF - Mechanics of Materials
M1 - 104520
ER -