Abstract
The agglomeration of paracetamol has been investigated by fully seeded isothermal crystallization experiments operated at constant supersaturation. The particles from crystallization in ethanol, methyl ethyl ketone, water and acetone-water mixtures are characterized by image analysis and multivariate data evaluation. The number of crystals in each agglomerated particle is characterized and used as a measure of the degree of agglomeration. Surfaces of large, well grown paracetamol crystals have been characterised by contact angle measurements and the Lifshitz-van der Waals acid-base theory to determine the crystal-crystal adhesion energy. It is found that, beyond the effect of differences in liquid viscosity and crystal growth rate, there is a dependence of the degree of agglomeration on the solvent composition that can be correlated to the free energy of adhesion.
| Original language | English |
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| Article number | B-42 |
| Pages (from-to) | 511-516 |
| Number of pages | 6 |
| Journal | VDI Berichte |
| Issue number | 1901 I |
| Publication status | Published - 2005 |
| Externally published | Yes |