Mechanostability of cohesin-dockerin complexes in a structure-based model: anisotropy and lack of universality in the force profiles

Michał Wojciechowski; Damien Thompson; Marek Cieplak

doi:10.1063/1.4904726

Mechanostability of cohesin-dockerin complexes in a structure-based model: anisotropy and lack of universality in the force profiles

Michał Wojciechowski, Damien Thompson, Marek Cieplak

Institute of Physics of the Polish Academy of Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We use a structure-based coarse grained model to elucidate stretching of three cohesin-dockerin complexes that are found in the cellulosome. The average strength of mechanostability is comparable to that of the I27 domain of titin, but the force profiles depend on the pulling direction and anisotropy effects can be substantial. Even though the force profiles for individual cohesins and dockerins are similar, those for their complexes are visibly distinct for any pulling direction.

Original language	English
Article number	245103
Pages (from-to)	245103
Number of pages	1
Journal	Journal of Chemical Physics
Volume	141
Issue number	24
DOIs	https://doi.org/10.1063/1.4904726 https://doi.org/10.1063/1.4904726
Publication status	Published - 28 Dec 2014
Externally published	Yes

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Mechanostability of cohesin-dockerin complexes in a structure-based model: anisotropy and lack of universality in the force profiles

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